Novel oral small molecule, mGluR4 effective in animal model

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Novel oral small molecule, mGluR4 effective in animal model

Postby MSUK » Tue Sep 25, 2012 3:07 am

Novel oral small molecule, mGluR4 effective in animal model of MS

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Addex Therapeutics, a leading company pioneering allosteric modulation-based drug discovery and development, has achieved a positive Proof of Concept for its lead metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM) compound series in a validated rodent model for multiple sclerosis (MS).

MS is a chronic inflammatory demyelinating auto-immune disease that affects the central nervous system (CNS), leading to serious disability.

"We are very excited that this promising Addex mGluR4 PAM series may offer a differentiated approach to treating MS," said Professor Ursula Grohmann, of University of Perugia, Italy, in whose laboratories one of these studies was performed. "These data confirm our previous observations, using an mGluR4 PAM tool compound called PHCCC, which demonstrated efficacy in the industry standard neuroinflammation model of MS, the Relapsing-Remitting Experimental Allergic Encephalomyelitis (RR-EAE) model. In this study, the mGluR4 PAM worked by promoting regulatory T-cell (Treg) formation and reversing pro-inflammatory T-cell release. Therefore, we believe that positive modulation of mGluR4 could potentially stop the destruction of myelin in MS in a robust and durable manner."...Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/3515
MS-UK - http://www.ms-uk.org/
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Re: Novel oral small molecule, mGluR4 effective in animal mo

Postby HarryZ » Tue Sep 25, 2012 11:19 am

squiffy2 wrote:Novel oral small molecule, mGluR4 effective in animal model of MS


Could this be the same mouse that despite researchers discovering a multitude of therapies that have stopped and/or reversed its MS, no therapy has ever gone on to help human MS?

MS is a chronic inflammatory demyelinating auto-immune disease that affects the central nervous system (CNS), leading to serious disability.


I didn't realize that anyone has proven that MS is actually an auto-immune disease.
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