EntreMed, Inc. announced today that preclinical results for its compound 2-methoxyestradiol (2ME2) were published on line in this week’s Early Edition of Proceedings of the National Academy of Sciences (PNAS). The study was conducted at The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital and was led by Tak W. Mak, Ph.D.
Tak W. Mak, Ph.D., Director, The Campbell Family Cancer Research Institute, commented on the study, “Multiple sclerosis (MS) is among the most common autoimmune disorders in the northern hemisphere. There exists significant unmet medical need for safe and effective drugs to treat MS. In this study, we demonstrated that 2ME2, an endogenous metabolite of estradiol, significantly inhibits lymphocyte activation and proliferation and dramatically suppresses development of experimental MS.
Our analysis of cellular signaling pathways further reveals that 2ME2 exerts a potent inhibition of Nuclear Factor of Activated T cells (NFAT). By extension, the study provides for the first time a molecular rational for the use of 2ME2 as a tolerable oral immunomodulatory agent for autoimmune disorders such as MS. Other studies have shown that in humans, plasma levels of 2ME2 may increase dramatically during the last months of pregnancy, which intriguingly appears to correlate temporally with the remission of clinical symptoms reported in some pregnant MS and rheumatoid arthritis (RA) patients. We believe that 2ME2 may offer a safe and effective treatment for such autoimmune disorders.”... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/2479