yea it seems to be a zinc dependent process. here's the relevant piece in my summary post (in the bloodwork section if you check the link)regimens-f22/topic2489.html#p15460
... the normal range for uric acid is 140-360 umol/L. MS patients average 194 umol/L. Healthy controls sit in the 290-300 umol/L range. Interestingly, uric acid levels are positively correlated with zinc levels. So if you are low in zinc you are likely to be low in uric acid too.
read more: http://www.sciencedirect.com/science/ar
fyi some people boost uric acid levels using inosine. that is a band-aid solution imho, and doesn't address the broken urea cycle (or associated high ammonia levels), which depends on proper liver function. addressing the low zinc level seen in ms patients provides the liver with the tools it needs to deal with ammonia properly, and uric acid levels rise as a result. the info is in the research and i have bloodwork of my own that corroborates the scientific findings.
more at wiki (i added the low uric acid section years ago, the cu/fe info has been added since by others)https://en.wikipedia.org/wiki/Uric_acid#Low_uric_acid
my conclusion is, zinc is so ubiquitous that when levels drop, a lot of wheels have the potential to come off. ms patients are known to be lower in zinc than healthy controls, and when it's low even for an ms patient, it would be reasonable to imagine that they would feel worse. too bad the uric acid researchers didn't also measure zinc. it has to be pieced together from a few different sources.
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com