have you ever looked into your magnesium or zinc levels? how's your vitamin e intake?
ms patients are recommended to obtain [up to 900] mg of elemental magnesium delivered to their system daily, from food (eg dark leafy green veg [as in chard and spinach, also halibut and chinook salmon and black beans]) and/or supplements (magnesium glycinate is best). target serum value is at least 0.91 mmol/L
ms patients also tend to be lower in zinc. food sources include red meat, oysters and pumpkin seeds (not sure about the relative bioavailability of zinc in vegetable foods). there is some earlier discussion of zinc forms in the forums, which should be searchable. try searching for terms like gluconate to tap into that discussion. target serum zinc level is abut 18 umol/L (i've seen other studies that range from 17-19 but you wouldn't want to get much higher [according to research, 30 umol/L is the top end of the recommended range]).
also make sure you get enough vitamin E. the blood tests out there aren't fantastic in my experience, but a good vitamin E rich diet (eg raw sunflower seeds) plus supplements (ONLY choose an E8 complex - nothing else is good enough, eg 'mixed tocopherols' are only half of the complex).
no target serum values for vit E yet. you could probably only easily get 1 test done, out of the 8 components of the complex.
the klenner protocol for ms uses 800IU vitamin E with three meals a day and again at bedtime (you don't do that forever though, it's a short term therapeutic megadose approach).
i would NOT follow the klenner recommendation to use d-alpha tocopherol acetate of d-alpha tocopherol acid succinate. the klenner protocol is old and he made his vit E recommendation based on the best info available at the time. nowadays, E8 complex is better.
i think i would consider trying one thing at a time, for a week at a time, to see if any specific one of these makes a difference over 2 or 3 days. i'm thinking zinc first, then mag, then e...
Chronic venous insufficiency... Depressed levels of zinc have been noted in patients with CVI and venous ulcer...
Zinc deficiency represents a risk factor for carotid stenosis (CS) development.
...patients with debilitating residual symptoms may be given nonspecific diagnoses such as "chronic pain syndrome." Although hypovitaminosis D is highly prevalent in patients with type 2 diabetes, to our knowledge, its impact on neuropathic pain has not been previously evaluated. ... A total of 51 patients with type 2 diabetes with typical neuropathic pain, including burning, tingling, numbness, and throbbing sensations ... were included... All patients were vitamin D insufficient, with mean serum 25D concentration of 18 ng/mL.
The mean serum 25D concentration in our patients was higher than "osteomalacic myalgic patients" reported in the literature (18 ng/mL vs <12 ng/mL). ... the improvement of pain in our subjects following vitamin D repletion could not be attributed to a decrease in parathyroid hormone level... the improvement in symptoms was independent of parathyroid status... The mean (SD) serum 25D concentration at 3 months in our study was 30 (5) ng/mL, which correlated with significant pain reduction.
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