Identifying the molecular causes of vision loss in demyelinating disease
Demyelinating diseases, such as multiple sclerosis (MS), are frequently associated with the progressive loss of vision. The retinal nerve damage is thought to be caused by immune system-mediated inflammation; however, other demyelinating disorders, such as Pelizaeus-Merzbacher disease (PMD), do not involve the immune system, suggesting that there are other causes of retinal nerve damage.
Deimination is a protein modification that is altered in patients with MS and PMD. In this issue of the Journal of Clinical Investigation, researchers led by Sanjoy Bhattacharya at the University of Miami investigated the role of deimination in retinal nerve damage in a mouse model of demyelinating disease (ND4 mice). ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1845