The research is about non-neurological conditions (sepsis, burns and trauma), but the point seems to be that the human immune systems is pretty drastically different from mice. With all DMD research starting from mouse models, I guess it's not too surprising that their results are so weak...Abstract
A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.