bananana wrote:I take Refif 44mcg. Also I take various supplements: Vit D, a multivitamin, ginko biloba, EGCG, turmeric, fish & flax oil. Oh, and naproxen to ward off the dreaded flu-like Rebif side effects.
I have low blood pressure
LR1234 wrote:Low BP 90/50 on average.
Got Hashimotos and Endometriosis (had them before MS)
I take Copaxone, LDN and supps I find help: Q10 200mg, Folic acid 800ug,B12 1000ug Inosine 500mg, Inositol/Choline 250mg, Asprin 150mg as well as Arixtra daily, Zinc/Vit C combo 8mg Zinc, (180mg Vit C), Vitamin D 5000iu
Chronic mild stress eliminates the neuroprotective effect of Copaxone after CNS injury
Igor Smirnova, James T. Walsha, b, Jonathan Kipnisa, b, ,
a Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
b Graduate Program in Neuroscience and Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
http://dx.doi.org/10.1016/j.bbi.2012.12.015, How to Cite or Link Using DOI
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Copolymer (Cop)-1, also known as glatiramer acetate, is an active compound of Copaxone, a drug widely used by patients with multiple sclerosis (MS). Copaxone functions in MS through two mechanisms of action, namely immunomodulation and neuroprotection. Because the immune system is suppressed or altered in depressed individuals, and since depression is often associated with neurological conditions, we were interested in examining whether the neuroprotective effect of Copaxone persists under conditions of stress-induced depressive behavior. We exposed mice to unpredictable chronic mild stress for 4 weeks and then treated them with three doses of Copaxone at 3-day intervals, with the last dose given immediately before the mice underwent a crush injury to the optic nerve. Whereas nonstressed mice exhibited a strong neuroprotective response after Copaxone treatment, this effect was completely absent in mice that underwent chronic mild stress. Interestingly, when Copaxone was combined with Prozac, the neuroprotective effect of Copaxone was regained, suggesting that chronic mild stress interferes with the neuroprotective effect of Copaxone. These results may shed a light on mechanism of action of Copaxone and lead to new combined therapies for neurodegenerative and neuroinflammatory disorders.
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