nairb86 wrote:Hi everyone:
Does anyone have any information on progressive-relapsing MS? Specifically typical initial symptoms and MRI results? I read somewhere that it attacks the neurons rather than the myeline. Any additional information would be helpful.
PRMS is defined by clinical symptoms (gradual progression with superimposed relapses). For instance, a person with PRMS could have slowly progressive insidious gait deterioration but have a discrete episode of optic neuritis. PRMS is not thought to be pathologically different from RRMS or SPMS. Often, the transition between RRMS and SPMS is indistinct and may be defined by fewer and fewer clinical relapses with increasing progressive symptoms.
MRI findings in PRMS can be different from SPMS in that PRMS patients may make new T2 lesions or even new enhancing lesions which are less common in SPMS.
Grey matter/cortical changes are now thought to be important in all forms of MS, especially progressive forms of MS.