PRMS

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

PRMS

Postby nairb86 » Thu Mar 21, 2013 7:26 pm

Hi everyone:

Does anyone have any information on progressive-relapsing MS? Specifically typical initial symptoms and MRI results? I read somewhere that it attacks the neurons rather than the myeline. Any additional information would be helpful.

Thanks!
nairb86
Getting to Know You...
 
Posts: 14
Joined: Wed Feb 13, 2013 1:14 pm

Advertisement

Re: PRMS

Postby mmpetunia » Sat Apr 06, 2013 6:07 pm

my understanding is that each subtype of MS attacks the same thing--myelin, just with varying time frames and possibly different patterns of findings on MRI. neurons get damaged after repeated attacks or increasing damage of surrounding neurons leading to axonal loss and scarring. but that happens with all the subtypes and is not unique to PRMS. hadn't put much effort into researching this subtype though, since it is very rare and doesn't really seem to fit my pattern of symptoms. although if you ask me, relapsing-remitting is a bit of a misnomer since the disease is always active even during "remitting" periods and is by definition a progressive disease (so decline is happening all the time).
Dx: 9/8/11 RRMS
OMS diet plus lean poultry
Tecfidera as of 8/21/2014
18+ brain lesions and 6 spinal lesions
EDSS 1.5-2
http://mylaceybrain.wordpress.com
mmpetunia
Family Elder
 
Posts: 101
Joined: Fri Dec 21, 2012 2:21 pm
Location: SF

Re: PRMS

Postby centenarian100 » Mon Apr 15, 2013 3:10 pm

nairb86 wrote:Hi everyone:

Does anyone have any information on progressive-relapsing MS? Specifically typical initial symptoms and MRI results? I read somewhere that it attacks the neurons rather than the myeline. Any additional information would be helpful.

Thanks!


PRMS is defined by clinical symptoms (gradual progression with superimposed relapses). For instance, a person with PRMS could have slowly progressive insidious gait deterioration but have a discrete episode of optic neuritis. PRMS is not thought to be pathologically different from RRMS or SPMS. Often, the transition between RRMS and SPMS is indistinct and may be defined by fewer and fewer clinical relapses with increasing progressive symptoms.

MRI findings in PRMS can be different from SPMS in that PRMS patients may make new T2 lesions or even new enhancing lesions which are less common in SPMS.

Grey matter/cortical changes are now thought to be important in all forms of MS, especially progressive forms of MS.

-c
centenarian100
Family Elder
 
Posts: 327
Joined: Mon Apr 15, 2013 10:51 am


Return to General Discussion

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service