There is a link between Th17 cell development and the endocrine system as this article shows:http://www.jbc.org/content/285/21/15668.full
I quote: ... demonstrates that RORα can induce the transcription of a FGF21 promoter-driven reporter. Inclusion of RORα resulted in an approximate 3-fold increase in FGF21 promoter-driven transcription. RORγ is structurally similar to RORα and displays an overlapping pattern of expression with RORα, and these two receptors cooperate to regulate diverse physiological functions including glucose metabolism and Th17 cell development. unquote
Now I don't exclude the possibility that -as the Ottawa study shows for people with aggressive MS-you can do something with bone marrow transplantation to get the Th17 cell development under control.
Just like you can do something with fecestransplantation to 'cure' MS and - I guess - get Th17 development under control.
Or through diet (Swank, Walsh) you may be able to get control over MS incl. I guess over Th17 cell development through rebalancing the endocrine system.. (see also general-discussion-f1/topic15188-375.html
What I find interesting to note here is that -with this highly complicated immuno driven appproach- Freedman apparently is able to margianalise risk where for other approaches such as ccsvi he was able to overemphasise risk and make other bold and inappropriate statements.