Non-toxic treatment in future?? Physically modified saline

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Non-toxic treatment in future?? Physically modified saline

Postby Anonymoose » Wed May 01, 2013 6:43 am

Protection of Tregs, Suppression of Th1 and Th17 Cells, and Amelioration of Experimental Allergic Encephalomyelitis by a Physically-Modified Saline
http://www.plosone.org/article/info%3Ad ... ne.0051869
How long before we get a human trial with saline? Too inexpensive/harmless for that?

I need to read through that with better focus when I have time. My usual random loose thread of thought is "I wonder if csf is like the saline in that it can be changed by physical conditions. That might explain some of the success of treatments that improve csf flow." Out there.

A bonus link from above paper: why helminths help with MS (at least in part).
http://m.jimmunol.org/content/173/2/1224.long

Happy reading! :)
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Re: Non-toxic treatment in future?? Physically modified sal

Postby CureOrBust » Wed May 01, 2013 7:16 am

http://www.prnewswire.com/news-releases/revalesios-rns60-protects-myelin-and-halts-multiple-sclerosis-in-mice-185529662.html
Revalesio is preparing to test RNS60 in a Phase II MS clinical trial at Mt. Sinai Hospital in New York.

RNS60 is distinct from other therapeutic candidates in that it does not contain a chemical active component and instead is comprised of charge-stabilized nanostructures (CSN) in saline. The use of CSN-containing therapeutics represents a fundamentally novel approach to treating diseases. RNS60 has demonstrated significant anti-inflammatory and cellular protective activity across numerous diseases and is being investigated for clinical relevance in multiple human disease trials. RNS60 has been tested in two Phase I safety studies and has demonstrated an excellent safety profile with no known side effects.


anyone want to make a phone call?

I am a little suspicious that nearly all results from a search in google brings up mostly links to the company that created this substance (ie Revalesio) :?
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Wed May 01, 2013 7:21 am

I'm shocked. I was going to google that later but had little hope of finding a trial. How cool is that?! Good on ya, cure!

I wonder if you have to be in NY area for trial. If I weren't doing the fenofibrate, I'd try to get in on this one.

Edit: Suspicious? Meh. Still worth a shot as it doesn't seem like waging chemical warfare in your body. There has to be some company out there operating in good faith, doesn't there? Maybe this is one.
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Wed May 01, 2013 7:38 am

Criticism of the paper
http://multiple-sclerosis-research.blog ... t.html?m=1

Hmmm. Salt deposits have been observed to be increasing with ms progression. Wonder how that plays into this.
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Wed May 01, 2013 8:30 am

Does anyone know/presume the rns60 is composed mainly of negatively charged salt ions? I cheated my way through chemistry...haven't a clue.
http://www.3kbioxml.com/3k/index.php/PJ ... le/200/128
If its the charge that helps (something has to be different about the salt since salt is being blamed for some of MS damage), I wonder if salt lamps wouldn't have a similar effect. Out there again.
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Wed May 01, 2013 4:13 pm

Okay. Salt lamps barely put out negative ions. And who knows if the rns60 has negatively charged ions after going thru the special process.

It does seem negative ions really do produce good feelings. There was recently a poster making claims about this without papers to back it up...he left. Here's a paper that speaks of it. http://aaqr.org/VOL11_No2_April2011/9_A ... 79-186.pdf

Way off original topic, methinks. Oh well. I'm definitely curious about the rns60 trial results.
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Re: Non-toxic treatment in future?? Physically modified sal

Postby CureOrBust » Wed May 01, 2013 5:22 pm

Anonymoose wrote:Edit: Suspicious? Meh. Still worth a shot as it doesn't seem like waging chemical warfare in your body. There has to be some company out there operating in good faith, doesn't there? Maybe this is one.
I am not saying its must therefore be a scam, just that I am a little suspicious that for a substance which is not patented or that difficult to produce, that it appears no independent third party have tried / succeeded to duplicate their results. :?:
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Re: Non-toxic treatment in future?? Physically modified sal

Postby blossom » Thu May 02, 2013 10:35 pm

CureOrBust wrote:
Anonymoose wrote:Edit: Suspicious? Meh. Still worth a shot as it doesn't seem like waging chemical warfare in your body. There has to be some company out there operating in good faith, doesn't there? Maybe this is one.
I am not saying its must therefore be a scam, just that I am a little suspicious that for a substance which is not patented or that difficult to produce, that it appears no independent third party have tried / succeeded to duplicate their results. :?:



i'm gonna try to follow this one myself. i hope others do too and report any finds back. one reason among others is that since it is as cureorbust said-suspicious of substance which is not patented or difficult to produce.--think of how many things-one of the top ten being marijauna--they did their best to keep it away from the sick and anythng else it threatened. if it's that good and that cheap and really can't be patented that easy like say honey there'd be no money in it like the drug co.'s are accustomed to. but, it sure would be worth it for the drug co.'s or others profiting from the sick to spend their money and influence to do all they could to stop it.--
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Fri May 03, 2013 6:11 am

Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline*
http://m.jbc.org/content/287/35/29529
That study involved 2 university research centers and revalesio. Is that better? Lol. I wish they explained the mechanism of action, preferably with diagrams and colorful pictures. There is an asthma/rsn60 study somewhere that claims the stable-charge of rsn60 corrects charge imbalances in the lungs during asthma attack or something like that. Is this what they are attempting to do with amiloride and other channel blockers??
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Re: Non-toxic treatment in future?? Physically modified sal

Postby CureOrBust » Fri May 03, 2013 7:32 am

Its still missing the independent third party requirement. Or in simple terms, again its Revalesio.
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Re: Non-toxic treatment in future?? Physically modified sal

Postby miri » Fri May 03, 2013 1:27 pm

While I don't understand the above URLs, some posts on this thread remind me of:

(1) sequential saltSea/mudpool (wonderful) which I posted elsewhere on these forums
.....and which, no, were not silly sulphur baths, nor silly-marketed Clay-baths or salt-packs

(2) the many diSodium-EDTA IV treatments which failed to help me

What i did not yet try, but sorta jives with my DeadSea experience, thus intrigues, is this:
http://www.eytonsearth.org/tdp-mineral-lamp-clay.php
It intrigues, cuz many toxic people are helped via F.I.R.(by itself, even without clay)
It intrigues also, cuz of thos Chinese factory women who never developed arthritis
Reachable via PM. Seems I have Higbee's HSII on ThisIsMS. Frustrated by MSers, FMers, Lymers & Prematurely-Aged-By-EMFers who prefer cryptic jargonian Systems Vs. Intuitive empirical experience. Don't simple truths count for anything anymore?
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Re: Non-toxic treatment in future?? Physically modified sal

Postby CureOrBust » Fri May 03, 2013 10:22 pm

CureOrBust wrote:Its still missing the independent third party requirement. Or in simple terms, again its Revalesio.
And anything from rush university should be viewed with the assumption that Revalesio are some way implicated.

Although not neurological, I did find this cardiology study on it, which I could not see a direct link with Revalesio:
http://content.onlinejacc.org/article.aspx?articleid=1664253
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Sat May 04, 2013 4:45 am

CureOrBust wrote:
CureOrBust wrote:Its still missing the independent third party requirement. Or in simple terms, again its Revalesio.
And anything from rush university should be viewed with the assumption that Revalesio are some way implicated.

Although not neurological, I did find this cardiology study on it, which I could not see a direct link with Revalesio:
http://content.onlinejacc.org/article.aspx?articleid=1664253


That one is revalesio too. Andrea Kalmes and probably the others are employees. Maybe rsn60 is too "ridiculous" like ccsvi PTA and no one else will touch it yet. I guess we will just have to see how it pans out.
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Re: Non-toxic treatment in future?? Physically modified sal

Postby blossom » Sat May 04, 2013 9:09 pm

wow, maybe there are some here that already read and know this scientist story but i had not. thought some that hadn't would be very touched as i am. "he happens to be at the forefront of all this"-and fate dealt him "als" and now he is his own human trial. he's certainly in my prayers-what a guy-what a brialliant mind. and as he states in this article YOU GOTTA TRY !

revalesio.com/.../dallas-scientist-is-now-his-own-experiment-in-testing-te...

CAN'T GET THE LINK TO COME UP- A LONG READ-SORRY. HAVEN'T FOUND YET HOW HE MADE OUT OR UPDATE. ANYBODY KNOW??'

Dallas scientist is now his ‘own experiment’ in testing tech to fight ALS
Reprint of article from The Dallas Morning News on Tuesday September 18, 2012. By MARC RAMIREZ

Date: September 18, 2012



Here’s how this is supposed to work: Things happen and science explains why.

But sometimes things happen that science can’t explain. And serendipity leads the way.

It’s when someone like Dallas scientist Tony Wood, struck with a fatal disease, finds himself unwittingly offering hope for his own despair.
For years, Wood put his tinkering, connect-the-dots mind to work for companies like Texas Instruments, filing dozens of patents and focusing on improving conditions for the less fortunate.

Fifteen years ago, he co-created technology to help grow plants in water that more recently has shown surprising, if mysterious, promise in treatment of neuro-inflammatory diseases such as muscular dystrophy, Parkinson’s and asthma.

Last year, safety studies were being conducted to pave the way for medical use of his device when Wood found himself struggling to shuffle cards or use the TV remote. Within months, he found he had ALS, or Lou Gehrig’s disease.

The disease has progressed unmercifully fast. Wood, 69, cannot lift his arms or move his legs. He can barely speak and uses his chin to operate his wheelchair. So discouraged by the disease’s rapid effects and his inability to tinker anymore, he was ready to give up.

Then he realized that ALS was among the set of diseases for which the oxygen-infused saline created by his technology could be potentially revolutionary.

He felt he had reason to live again.

With Food and Drug Administration approval, he’s volunteered to be his own guinea pig. He’s now a one-man research trial, working with a UT Southwestern Medical Center neurologist and a product he himself made possible.

As he puts it: “I am my own experiment.”

Mystery of ‘nanobubbles’

As a boy, Wood worked in a Dallas electronics shop, repairing TVs, irons and vacuum cleaners. “I had an insatiable curiosity about how things worked,” he said.

He graduated from Jesuit College Preparatory School of Dallas and earned a degree in physics from the University of Texas at Arlington. That led to a career at Texas Instruments and then his own scientific venture, which he sold in 2004.

Ever the tinkerer, he rebuilt Jeeps and remodeled homes around his Lakewood neighborhood in his spare time.

In the late 1990s, Wood was in his garage, trying to find ways to rapidly fold gases into liquids.

“He thought it could help with wastewater treatment or ethanol production,” said Richard Watson, chief science officer for Tacoma-based Revalesio, the firm that bought Wood’s company in 2004. “He’s such a visionary on a lot of fronts.”

Though he didn’t yet realize it, the machine he would devise marshaled the forces of “nanobubbles,” microscopic bubbles that science says shouldn’t exist. And yet, somehow they do.

It’s hard enough for regular-size bubbles to exist. Their thin walls burst once external pressure overpowers the gas force inside them. The smaller the bubble, the less likely it can withstand those outer forces; in fact, the internal pressure would have to rival that found a kilometer below sea level.

“Would-be nanobubbles [should] collapse before they can even form,” an article in New Scientist magazine said in its July issue.

And yet, as scientists around the world began to show in experiments with water-resistant surfaces, they did exist.

“No one can say how,” New Scientist wrote. “So far none of the proposed explanations quite has the ring of truth.”

Wood, meanwhile, was busy pondering. Plant growth was already accelerated in hydroponic environments. What if you could infuse that water with oxygen? What could that do for food production in remote Third World communities?

He and engineer Norm Wooten devised a prototype, and the so-called “food machine” is now at work in Cambodia.

“I certainly did not start out wanting to find a nanobubble,” Wood said. “All I wanted to do was put more oxygen in the water.”

But in time, others considered the technology’s potential medical uses; in 2007, Stanford University researchers showed that oxygen-infused saline could produce steroid-like anti-inflammatory results.

“We thought: If that’s true, all these inflammatory diseases should be beneficially affected,” Revalesio’s Watson said.

Multiple sclerosis, Alzheimer’s, Parkinson’s — whatever sets off these neuro-inflammatory diseases, a common thread of chemicals binds them as they crescendo toward destruction of the body’s central nervous system.

The oxygen-enriched saline, called RNS60, seems to shut those chemical processes off, he said, and results of the company’s studies have begun to emerge in publications such as The Journal of Biological Chemistry.

Phase 2 clinical trials for asthma and multiple sclerosis are planned or under way.

More work to do

Last year, Wood flew to a science conference at Oxford. He remembers his left leg buckling as he got off the plane. A result of the long flight, he figured.

But his body continued to weaken. Eventually, his hands began to curl. He was diagnosed with ALS and is now on permanent disability.

“Some people may not get to this stage for years,” said Janel Wood, his wife of 25 years. “Tony got to this stage in months.”

Two days after Christmas, Wood woke up so weak he couldn’t get out of bed. He was rushed to the hospital and placed in intensive care.

Then, he said, he had a vision. The message: You have more work to do.

The doctors presented the papers he and Janel had filled out with a “do not resuscitate” directive should it come to that. All he had to do was sign. “Is this what you want?” they asked.

Unable to speak, he shook his head no. And using the letter chart Janel had designed for him to communicate, he spelled out three words:

I GOTTA TRY.

Janel still remembers that day in the ICU, when Tony suggested that doctors try using RNS60 on him. “They just listened politely,” she said.

Now, twice a week, she takes Tony to the infusion clinic at UT Southwestern for exactly that. Wood’s regimen, approved by the hospital’s internal review board and sanctioned by the FDA as a single-patient trial for ALS, began in March.

Recently, Janel piloted Wood’s motorized wheelchair into the clinic, where nurse Natasha Jones probed for the vein on the back of his hand into which the fluid would be injected.

Because ALS progresses differently in each individual, it may be hard to determine much from the one-person trial unless Wood’s disease stops completely or significantly. But Watson said his symptoms seem to have reached a plateau.

What doctors hope to see are measurable side effects or signs of increasing muscle strength.

“It could take months to be able to see that,” said UT Southwestern neurologist Jeffrey Elliott. “We’re patient.”

Shoeless and stiff in his spiffy purple shirt, fresh off a tracheotomy, Wood looked frail, a long way from the robust, pony-tailed scholar who once split time between Dallas and Tacoma as Revalesio’s research and development director.

Unable to swallow, his speech slurred and nearly indecipherable, he craved the simple pleasures of coffee and Klondike bars.

Though his body cannot work, his mind can. His toughest challenge now is dealing with the frustration of being unable to contribute as he once did, but the Woods plan to travel to Tacoma by month’s end so he can continue to offer his expertise.

He’ll continue his treatment there, working with doctors at the University of Washington.

“Yes, it would be best if he could walk and talk and move his arms,” Janel said. “But inside, he’s still the same. Patents are happening all over the place, and he wants to be there.

“I’ve heard him say so many times that science is really about failure. Over and over you might fail, but that one time you really do solve the problem, then all the doors open up.”

Pursuing failure might seem futile to some. But for a man who is now a lab rat for his own invention, an invention based on a phenomenon that scientists say shouldn’t exist — well, maybe that’s more like faith.

The experience, Wood said, has given him a deeper spiritual understanding of himself.

“I am much more than flesh and bones,” he has written. “I am an active, participating human, aware of being in service to others.”

Dallas Morning News Article: http://www.dallasnews.com
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Re: Non-toxic treatment in future?? Physically modified sal

Postby Anonymoose » Sun May 05, 2013 6:18 am

Good find, blossom! I second that "wow!" I may be a sucker but that gives me a bit more faith in this rns60. I hope Woods continues to experience improvements.

I found this on a revalesio page...
http://revalesio.com/2013/01/revalesios ... #more-1564
Revalesio has pioneered the use of RNS60 as a therapeutic that alters whole cell conductance through effects on voltage-gated ion channels and other voltage-sensing proteins, thereby modulating the activity of G protein-coupled receptors and the secretion of cytokines resulting in decreased inflammation and cell death. RNS60 contains CSN that are created by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow. RNS60 has demonstrated a reduction in inflammatory responses that are linked to numerous diseases, including neurodegenerative, respiratory and cardiovascular diseases.

It seems rns60 is targeting the voltage gated channels like amiloride.
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