echinacea for ms!?!

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

echinacea for ms!?!

Postby jimmylegs » Fri Mar 31, 2006 6:02 pm

i think i'm going to guinea pig myself and try it! if the auto-immune theory is disputed, and if the home page article says more natural killer cells are good, then hell yea! i'd say that speaks to the good ol' virus theory, wot wot? i'm throwing immune system caution to the wind and takin me some echinacea.

Biogerontology. 2005;6(3):157-63.
Enhancement of natural killer cells and increased survival of aging mice fed daily Echinacea root extract from youth.
Brousseau M, Miller SC.
Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.

In spite of Echinacea-based products being among the best-selling herbs in the world to date, to allay assorted ailments, the debate is still on-going with respect to the efficacy of ingesting the herb intermittently, continuously, or only at the beginning of an affliction. We sought, therefore, to find out if mice, receiving dietary Echinacea daily, throughout life, from youth until late middle-age, demonstrated any longevity/survival differences, and/or any differences in their various populations of immune/ hemopoietic cells. Sustained and/or high levels of these cells are crucial for longevity. Some mice were maintained on a regular chow diet to which was added Echinacea purpurea daily (2 mg/mouse), from puberty (7 week) until just beyond 13 months of age (late middle-age in mice). Control mice, identically housed and maintained, received identical chow without the herb. Mice consuming untreated diet had a 79% survival by 10 months of age, while those consuming Echinacea daily in the diet were still 100% alive by 10 months. At approximately 13 months of age, mice consuming untreated diet had a 46% survival rate while those consuming Echinacea, were 74% alive at this time. Moreover, the key immune cells, acting as the first line of defense against developing neoplasms in mice and humans, i.e., natural killer (NK) cells, were significantly elevated in absolute number both in their bone marrow production site, as well as in the major organ to which they traffic and function, i.e., the spleen. The cells of the myeloid/granulocyte lineages remained steadfastly at control levels in both the bone marrow and spleen in Echinacea-consuming mice. Thus, it appears that regular intake of Echinacea may indeed be beneficial/prophylactic, if only for the reason that it maintains in an elevated state, NK cells, prime elements in immunosurveillance against spontaneous-developing tumors, a phenomenon which increases in frequency with progressive aging.



Echinacea purpurea and Melatonin Augment Natural-Killer Cells in Leukemic Mice and Prolong Life Span
Jun 2001, Vol. 7, No. 3: 241-251

Nathan L. Currier, BSc
Department of Anatomy & Cell Biology, McGill University, Montreal, Canada
Sandra C. Miller, PhD
Department of Anatomy & Cell Biology, McGill University, Montreal, Canada

Objective: We recently showed that daily dietary administration of Echinacea purpurea root extract to normal mice for as little as 1 week resulted in significant elevations of natural-killer (NK) cells (immune cells that are cytolytic to virus-containing cells and many tumor cells). Such boosting of this fundamental immune cell population suggests a prophylactic role for this herb in normal animals. Based on this evidence, our goal in the present work was to assess the role of dietary administration of this herbal extract to mice bearing leukemia, a type of tumor well known to be a target for NK cells.

Design: A commercially available root extract of E. purpurea, which we have already shown to be highly effective in mice, was administered daily for 50 days from the onset of leukemia (day 0). Control leukemic mice received no extract. Other leukemic mice received the NK-enhancing neurohormone, melatonin, administered precisely as above.

In all treatment and control categories, some mice were sampled at 9 days after tumor onset, others were sampled at 3 months, and still others were left to assess treatment effect on life span.

Results: At 9 days (intermediate stage leukemia; death beginning by day 17-18), E. purpurea–treated mice had a 2.5-fold increase in the absolute numbers of NK cells in their spleens. By 3 months after leukemia onset, E. purpurea–treated mice still had 2–3 times the normal numbers of NK cells in their spleens. No leukemic, untreated (control) mice remained alive at 3 months, hence the comparison with normal animals. Moreover, at 3 months post-tumor onset, all the major hemopoietic and immune cell lineages in their bone marrow birth site, were recorded at normal numbers, in E. purpurea-consuming, leukemic mice.

The survival advantage provided by administering these leukemic mice with E. purpurea was highly significant versus untreated, leukemic mice when analyzed by Kaplan-Meier survival statistics.

Conclusion: The present study has provided the first systematic analysis, under controlled laboratory conditions, of the effect(s) of the botanical, E. purpurea, in vivo, in leukemic hosts. The profoundly positive effects of this herb in disease abatement observed in this study suggest the therapeutic potential of E. purpurea, at least with respect to leukemia, if not other tumors as well.
jimmylegs
Volunteer Moderator
 
Posts: 9151
Joined: Sat Mar 11, 2006 3:00 pm

Advertisement

Postby Arron » Fri Mar 31, 2006 7:14 pm

Jimmy, I understand your post, but to be clear to all the readers out there--

As you know, we don't provide medical advice on this site, and no one here is qualified to do so, nor claims to be.

The home page article talks about research that suggests raising the natural killer cells *in this particular trial* has been good, but there are potentially many complicating factors that we don't know about.

In other words, please make your medical decisions with the consent of your doctor, or you are potentially placing your health at risk. A very large part of the medical community would strongly advise against MS'ers boosting their immune system.
Disclaimer: Any information you find on this site should not be considered medical advice. All decisions should be made with the consent of your doctor, otherwise you are at your own risk.
User avatar
Arron
Volunteer Moderator
 
Posts: 892
Joined: Sun Feb 01, 2004 3:00 pm
Location: California, USA

Postby oreo » Fri Mar 31, 2006 7:30 pm

I have read that taking the stuff is a big NO-NO if you are taking any of the CRABs. Echinacea and the CRABs work in opposing directions. None of us needs a bigger war going on in our bodies than the one we already have.
Carpe Diem
User avatar
oreo
Family Elder
 
Posts: 166
Joined: Fri Jun 04, 2004 2:00 pm
Location: Canada - Ontario - South-West

echinacea disclaimer

Postby jimmylegs » Sat Apr 01, 2006 6:29 am

yea to anyone who suddenly thought they would also like to throw caution to the wind and be an echinacea guinea pig, just so u know, that is not medical advice :wink:
jimmylegs
Volunteer Moderator
 
Posts: 9151
Joined: Sat Mar 11, 2006 3:00 pm

Postby Brownsfan » Sat Apr 01, 2006 6:31 pm

oreo wrote:I have read that taking the stuff is a big NO-NO if you are taking any of the CRABs. Echinacea and the CRABs work in opposing directions.


Actually, according to Teva Pharmaceuticals, Copaxone does not suppress the immune system. Maybe echinacea and RABs work in opposing directions but glatiramer isn't an interferon.
User avatar
Brownsfan
Family Member
 
Posts: 91
Joined: Thu Aug 25, 2005 2:00 pm

Postby Arron » Sun Apr 02, 2006 8:43 pm

lol thanks jimmy ;)
Disclaimer: Any information you find on this site should not be considered medical advice. All decisions should be made with the consent of your doctor, otherwise you are at your own risk.
User avatar
Arron
Volunteer Moderator
 
Posts: 892
Joined: Sun Feb 01, 2004 3:00 pm
Location: California, USA

here goes nothin!

Postby jimmylegs » Sat Apr 08, 2006 3:50 pm

well, today for the first time, 20 echinacea drops, plus one drop oil of oregano, have been added to the array of vitamins, minerals, and other stuff going in daily. FYI: oil of oregano is :twisted: :!: HOT :!: :twisted:
jimmylegs
Volunteer Moderator
 
Posts: 9151
Joined: Sat Mar 11, 2006 3:00 pm

natural killer/MS abstract

Postby jimmylegs » Sat May 13, 2006 6:36 am

ok is it just me, or is it starting to look even more as if echinacea, with its documented boosting of natural killer cells, might be a GREAT way to slow or halt lesion development? i will happily be the canary in the coal mine here. ;)

J Neuroimmunol. 1998 Jun 15;86(2):123-33. Related Articles, Links

A role for natural killer cells in the immunopathogenesis of multiple sclerosis.
Kastrukoff LF, Morgan NG, Zecchini D, White R, Petkau AJ, Satoh J, Paty DW.
Department of Medicine, University of British Columbia, Vancouver, Canada. lornefk@unixg.ubc.ca

Seventeen relapsing-remitting (R/R) multiple sclerosis (MS) patients and age/sex matched controls were studied every 6 weeks for 2 years. Disease activity, determined both clinically and by serial MRI, was correlated with natural killer (NK) cell functional activity (FA) and phenotype. Mean NK cell FA is significantly lower in MS patients, compared to controls (P < 0.001), while variability around the means is significantly greater (P < 0.01). The spectrum of mean NK cell FA, observed in the patient cohort, along with cyclical nature of the FA and phenotype over time, observed in both patients and controls, may begin to explain the discrepant results reported in previous studies. In R/R MS, there is a significant correlation between reductions (valleys) in NK cell FA and the development of active lesions on MRI, new (P < 0.001) or enlarging (P = 0.05). More importantly, a significant number of active lesions, new (P = 0.01) and enlarging (P = 0.02), are preceded by a reduction in NK cell FA. The correlation between the onset of clinical attacks and valleys of NK cell FA is also significant (P = 0.002). When taken together, the results suggest that reductions (valleys) in NK cell FA represent periods of susceptibility for the development of active lesions on MRI and clinical attacks. A significant positive correlation is also identified between mean NK cell FA for each R/R MS patient and total number of active MRI lesions developed by that patient over the 2 years (P = 0.001). The results would suggest that R/R MS patients with a higher mean NK cell FA are at greater risk for the development of active lesions. These results support the proposal that NK cells may play a role in the immunopathogenesis of R/R MS.
jimmylegs
Volunteer Moderator
 
Posts: 9151
Joined: Sat Mar 11, 2006 3:00 pm

full circle

Postby jimmylegs » Sat May 13, 2006 7:02 am

hmm how besides echinacea can we make sure those natural killer cells do their thang...

Mech Ageing Dev. 1998 May 15;102(2-3):279-92. Related Articles, Links
Natural immunity and bone and muscle remodelling hormones in the elderly.
Mariani E, Ravaglia G, Meneghetti A, Tarozzi A, Forti P, Maioli F, Boschi F, Facchini A.

Laboratorio di Immunologia e Genetica, Istituto Codivilla Putti IOR, Bologna, Italy. marianie@alma.unibo.it

Increasing evidence has demonstrated that the immune system is closely integrated with two other physiological systems: endocrine and nervous. They communicate through circulating humoral factors such as cytokines, hormones and neurotransmitters. We undertook a cross-sectional analysis in a group of elderly subjects over 90 years to demonstrate that a functional relationship exists among the number and cytolytic activities of NK cells, bone and muscle remodelling hormones, anthropometric parameters and physical ability. Peripheral blood samples collected from 62, 90-106 years-old subjects underwent biochemical (bone and muscle remodelling hormone levels) and immunological determinations (Natural Killer cell distribution and activity), anthropometric and functional assessment. Significant associations were found among NK cell number and cytolytic activity and serum concentrations of vitamin D, anthropometric parameters, while functional independence in daily activity was only associated with NK cell number. In general a high level of physical ability was correlated with preserved body stores and vitamin D levels. In conclusion, our results stress the importance of nutritional evaluation in the clinical assessment of elderly people. The magnitude of the NK immune response, which constitutes the first line of defence against infected and neoplastic cells, is best preserved in oldest-old people with the best hormonal parameters and nutritional measures.

for more vitamin d abstracts...
http://www.thisisms.com/modules.php?name=Forums&file=viewtopic&t=2246
jimmylegs
Volunteer Moderator
 
Posts: 9151
Joined: Sat Mar 11, 2006 3:00 pm


Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service