Hi Rick~I just wanted to make a few more points on vitamin B12 and D, and these missing enzymes, which might be helpful as you search for a cause of your illness.
First-a lack of vitamin B12 and D would result from these missing enzymes (protease and DNase1) Since I believe the evidence shows that all autoimmune diseases originate with these enzymes, you would expect to see the exact same symptoms and findings in any systemic autoimmune disease as you see in MS. Your "diagnosis" will be based on your most current severe manifesting symptom, or on the severity of the disease process as determined by bloodwork, MRI etc.
Remember, according to Mayo College of Medicine, "numerous studies have implicated protease in MS."
Now, take another autoimmune disease, such as Sjogens syndrome (dry eyes and mouth). Sjogens patients also lack these enzymes. Since these enzymes are necessary to bind and transport vitamin B12 and to carry protein-bound calcium, which is essential for proper vitamin D metabolism, you would expect Sjogrens patients to also lack vitamin B12 and D, just as MS patients do.
Here is a study on the B12.
Iron and vitamin deficiencies, endocrine and immune status in patients with primary Sjögren’s syndrome.
Lundström, I.M., F.D. Lindström. 2001. Oral Dis. 7(3):144-9.
“…In total, current or previously treated iron and vitamin deficiencies were registered for 63% of the 1st degree SS patients (iron 51%, vitamin B12 25%...thyroid disease was found in a total of 33% and 30% had had autoimmune thyroiditis… Rheumatoid factor (RF) was detected in 85%...”
Here is the info on the vitamin D. http://www.lef.org/news/LefDailyNews.ht ... n=VITAMINS
Recent findings seem to show that low vitamin D levels in patients with SS could be associated with severe complications such as lymphoma and peripheral neuropathy. According to the news reporters, the research concluded: "Vitamin D supplementation may be an additional tool for optimization of SS treatment."
For more information on this research see: Novel aspects of Sjogren's syndrome in 2012. Bmc Medicine, 2013;11():93. (BioMed Central - http://www.biomedcentral.com/;
Bmc Medicine - http://www.biomedcentral.com/bmcmed/
Low vitamin B12 will lead to "white matter lesions" since vitamin B12 is necessary to maintain myelin. You would therefore expect to find white matter lesions in Sjogrens on par with those found in MS. The following study confirms that this is the case.
In the following study when fifty-eight Sjögren syndrome (SS) patients with neurologic manifestations associated with SS had magnetic resonance imaging (MRI) of the brain, the researchers found that 70% of the patients had white matter lesions and 40% met the radiologic criteria for MS.
Medicine (Baltimore). 2004 Sep;83(5):280-91.
Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients.
Delalande S, de Seze J, Fauchais AL, Hachulla E, Stojkovic T, Ferriby D, Dubucquoi S, Pruvo JP, Vermersch P, Hatron PY.
Department of Neurology, CHRU Lille France
“…We retrospectively studied 82 patients (65 women and 17 men) with neurologic manifestations associated with primary SS, as defined by the 2002 American-European criteria…Thirty-three patients had brain involvement and 13 patients had optic neuropathy. The disease mimicked relapsing-remitting multiple sclerosis (MS) in 10 patients and primary progressive MS in 13 patients… Thirty percent of patients (all with CNS involvement) had oligoclonal bands… Fifty-eight patients had magnetic resonance imaging (MRI) of the brain. Of these, 70% presented white matter lesions and 40% met the radiologic criteria for MS…”
You would also expect to find evidence of these missing enzymes in Sjogrens.
In the following study the researchers identified subclinical exocrine pancreatic insufficiency in not only Sjögren’s syndrome, but in rheumatoid arthritis (RA) patients as
well. In the Sjögren’s patients tested, 58.3% had a “significant decrease” in pancreatic enzymes. [The exocrine pancreas is where DNase1 and protease originate]
Pancreatic duct antibodies and subclinical insufficiency of the exocrine pancreas in Sjögren’s syndrome.
D’Ambrosi, A., A. Verzola, P. Buldrini, C. Vavalle, S. Panareo, S. Gatto, R. La Corte, L.
Vicentini, A. Boccafogli, R. Scolozzi. 1998. Recenti Prog Med 89(10):504-9.
“In previous studies we reported evidence of subclinical exocrine pancreatic insufficiency in primary or secondary Sjögren’s syndrome (SSI, SSII) and rheumatoid arthritis (RA)…test results, compared to controls, showed a statistically significant decrease in duodenal juice volumes, bicarbonates and enzymes in 58.3% of SSI, and in 30% of RA…”
In an additional study entitled “Exocrine pancreatic function in Sjögren’s syndrome” the researchers concluded, “Exocrine pancreatic impairment was found to be present in 63% of the patients” (Coll, 1989).
You can do this with every autoimmune disease. They are all connected to the exact same disease pathway.