I have heard that idebenone could possibly help in massive doses. But it's practically impossible to get these days. It didn't do anything for me because I think you have to get it in that window of time after the ON. I also notice the improvement with Niacin. I also see it with bromelain when taken on an empty stomach (which thins the blood by reducing fibrinogen. Again, a blood flow issue. That's why I've followed the swank diet for six years now. Less saturated fat means thinner blood. When I gave blood recently, the guy commented on how I must be a runner because my blood was so healthy. I don't run; I just eat light. I've also noticed differences in vision after alpha lipoic acid and magnesium. But I can't say anything for B1. Does an oral klenner regimen work?