grandsons4 wrote:Orion98665, Hi: The article in Discovery had me on the edge of my seat like a good sci-fi movie. I wonder if infectious agents, such as the ones mentioned, contribute "missing pieces" of code to HERVs, enabling them to replicate?? Also, is it possible these HERVs exist in myelin, and are recognized there (more readily then elsewhere) by the immune system? I was attempting to read and understand the second article when my head exploded. I did manage to jump to the summary where they more precisely pinpointed the mechanism/s by which EBV persists, and thereby establish a potential target of future treatments. Thanks.
Scott1 wrote:Hi Anonymoose,
Rituxumab is a monoclonal antibody that targets B cells. I tried to get my doctor to give it to me but he has a blind spot about them as his own sister died from an adverse reaction to one of them. A monoclonal antibody is a designer antibody that has been optimised to perform a certain function by binding exclusively to one domain in a V shaped vector. If it does more than that then it may do something disastrous.
Without going into detail I think two things are going wrong. The precondition relates to endothelial dysfunction. This gives rise to iNOS where eNOS or nNOS should exist. I suspect this goes right back to birth and relates to an adrenal malfunction (which we may grow out of) but is obviously slow to manifest as a problem. The health of the mother may be an issue but how will we ever know. I am suspicious that something is awry with the retinoids and Vitamin A way back at that stage which set us on the wrong path. (My pet idea which lacks sufficient research based evidence). This endothelial dysfunction is metabolic.
The second element involves a viral trigger. The most obvious candidate is EBV but it could be something else that is persistent and promotes Superoxide. EBV stays resident in B cells and "breeds up" as we make new B cells. Again this takes time. It is not really autoimmune as it is not the immune system attacking the host, it is the B cell being altered. Rituxumab should address this but it won't be looking at the accumulation of damage from endothelial dysfunction. Adding Arginine will help the endothelium to recover but it won't stop the permanent damage already done by Peroxynitrite or stop the replication of EBV.
Many people have EBV without symptoms but they don't have low uric acid or endothelial dysfunction as well. Elevating Uric acid (by diet or medication) helps scavenge Peroxynitrite. High Uric acid tops out with gout symptoms so MS symptoms lessen as the peroxynitrite is mopped up.
My approach is aimed at doing several things 1) lower Peroxynitrite by limiting Superoxide and 2) repair the endothelium.
The Valtrex and now the Resvesterol are all about disrupting the EBV to lower the viral load and hence lower superoxide. The Arginine is all about repairing the endothelium to lower iNOS. Carrot juice is about retinoids to elevate RXR and hopefully heal the gut at the same time. Olive leaf extract is to elevate PPAR to help the lipids. The probiotic helps the mucked up gut flora. The coenzyme Q10 is to boost ATP as I assume this step permanently damaged and can't help cell function properly any more.
I'm not sure what to suggest about the oestrogen issue. I haven't looked at that issue in any detail. Someone else may have a better idea. Can you provide more colour around that topic? Is it based on what you have read or how you feel? Can there be contraindications with other things you are taking?
I'm sure there are many ways to skin a cat but the structure of what I do is working very well for me.
Scott1 wrote:Hi Anonymoose,
I am clearly not on firm ground but your symptoms sound to me that they are triggered by falls in Progesterone levels. That should happen in a normal cycle at the appropriate time. I can't find a reference that suggests Resvesterol causes that so it may be something else.
Some things I read suggested Progesterone deficiency could also be described as an Estrogen dominance . Other references noted adrenal malfunction.
I'm not sure where I can go with this as I'm not strong in this area. Maybe there is a medication or other factor at play and Resvesterol is an coincidental involvement.
Just a suggestion.
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