12% of MS patients have autoantibodies against RBPJ protein

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12% of MS patients have autoantibodies against RBPJ protein

Postby frodo » Sat Sep 07, 2013 3:18 am

It seems again that MS is an heterogeneous disease. An specific autoantibody appears in 12% of the patients, suggesting different pathogenesis.

http://www.ncbi.nlm.nih.gov/pubmed/23921886
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Re: 12% of MS patients have autoantibodies against RBPJ prot

Postby RyanYum » Sat Sep 07, 2013 9:03 am

that's only 12% isn't that indicative that those people have an infenction of epson barr and of course they'd have the anti for that disease.

Maybe someone could weigh in and clear this up
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Re: 12% of MS patients have autoantibodies against RBPJ prot

Postby grandsons4 » Sat Sep 07, 2013 9:14 am

They do point out that "this difference in reactivity was restricted to the CSF as serum reactivity against RBPJ did not differ between patients and controls." Perhaps another marker in the breakdown of the BBB.
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Re: 12% of MS patients have autoantibodies against RBPJ prot

Postby Scott1 » Sat Sep 07, 2013 3:01 pm

I must say I don't like anything about how the conclusion has been drawn. I'm sure EBV has a role in most cases but this work makes much too big a leap for me. Perhaps they can build on it and come up with something more tangible.

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