Well guys, here’s another limb on the hormone tree.
In considering whether infection with another virus reinitiates CNS infection later in life, I also wonder if “adrenopause
”, when DHEA levels begin to fall in men and women, could also be a factor that might allow dormant viruses (or bacteria) in the CNS to become active later in life.
I’ve already posted the animal info about DHEA and the possibility it may protect against bacterial
and viral infections
Intra-individual maximum concentrations of DHEA and DHEAS are achieved during the third decade, followed by a steady decline with advancing age…This decline has been termed “adrenopause”…The age-related decline in DHEA(s) levels show high interindividual variability…Adrenopause is independent of menopause and occurs in both sexes as a gradual process at similar ages.
Another take on adrenopause
notes it is an imbalance between DHEA and cortisol secretion
Several clinical signs might be related to the decline of DHEA secretion in aged people: ………..impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences……..
There has in fact been some research to suggest people with MS may have a dysfunction in DHEA and cortisol secretion
A little OT, but the info on daclizumab peaked my interest in natural killer cells. It was recently reported that DHEAS effectively “corrected” two other “auto-immune” diseases by virtue of some impact on natural killer cells. Defect of a Sub Population of Natural Killer Cells in Graves’ Disease and Hashimoto’s Thyroiditis: Normalizing Effect of DHEAs
CONCLUSIONS: A functional defect of a subpopulation of NK immune cells, involving both NKCC and the secretory activity, was demonstrated in newly-diagnosed GD and HT patients. This defect can be reversed by a dose-dependent treatment with DHEAS.
At any rate, the hormone barker thinks low levels of DHEA in people with MS could be a contributing factor to the “re-emergence” of viral and/or bacterial infections later in life. If DHEA in fact affords some protection against viral and bacterial infections in humans (an unknown I think), DHEA levels start dropping during our 30’s (adrenopause and the “decade of diagnosis”) and DHEA is an immune modulator, it at least seems like DHEA could theoretically be considered as another factor that might contribute to the “re-emergence” of infections in people with MS in adulthood.
Just more speculation from the hormone corner….
Maybe the "real news" is that I posted something with an "auto-immune" spin.