mrbarlow wrote:This post is following a general observation but I think Linda is our chief expert on such matters. I am flattered, but do not consider myself an expert.
For several weeks my symptoms have been getting worse - predominantly daytime fatigue and brain fog to the point its affecting my work. Terribly itchy skin, parathesia in my feet and hands, and electrical pulses in my arms and legs.
This virtually all came to an end yesterday.
Instead of of eating my usual bowl of oat based museli with soy milk I got up late for work and scoffed 3 lean beef sausages as breakfast. Also had an apple mid morning. Salad for lunch (cabbage, carrot and cucumber), and chicken stire fry for dinner with a little white rice.
Despite less than optimal sleep I feel very awake and sharp. No skin itch and only a tiny amount of parathesia in the extremities. No noticable electrical pulses or twitches. Today followed the same routine - Cold lean sausages for breakfast, mid morning apple, and salad lunch. Its early afternoon here and I feel great.
Anyone is free to pitch in but LInda if you are reading can you offer me some advice here as to what if anything I need to do next? I can only think that your situation might be the same as what I suspect mine to be: Intestinal Permeability (IP a.k.a. Leaky Gut) is allowing too much insulin into the bloodstream. I suggest you eliminate any "sweet" sensation on the tongue or palate (simply a sweet taste triggers a first release of insulin) and severely limit the foods that convert to glucose/blood sugar (blood sugar stimulates the pancreas to secrete a second release of insulin). Next, assume you have Leaky Gut, avoid all grains – even oats – because the gluten proteins in grain increase zonulin, which opens the tight junctions of the intestines. Some people suspect that even soy, in all its forms, is not a good choice. Add probiotics, aloe vera, coconut oil to your regimen. This is the program I have started this week – good luck to us both!
I don't have the other symptoms for diabetes and I don't recall any blood sugar issues in the past. I had thought I might be wheat intolerant (I think you could be right about this.) but now think this is a carbs / insulin issue (I think this is involved, also.).
mrbarlow wrote:Kept off the cereals all week and have felt great with virtually no 'MS' symptoms. One day had a subway roll for lunch as away on business and hey presto felt like $hit for the next 5-6 hours.
BBB or gut, it's all membrane integrity at the end of the day
Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components
"As well as having nutritional value, trace elements such as zinc may also assist with the maintenance of intestinal barrier integrity. Caco-2 cells grown in zinc-deficient media have reduced TEER (transepithelial electrical resistance) and altered expression of ZO-1 and occludin (localized away from the cell boundaries, less homogenous) compared with Caco-2 cells grown in zinc-replete media (92). This is accompanied by disorganization of F-actin filaments."
the benefits of probiotics and lots of other things are mentioned in this article also.
the article cited this source:
Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells
http://jn.nutrition.org/content/138/9/1664.shortZinc may contribute to the host defense by maintaining the membrane barrier. In this study, we questioned whether zinc deficiency affects the membrane function and junctional structure of intestinal epithelial cells, causing increased neutrophil migration. We used the Caco-2 cell line grown in control (C), zinc-deficient, or zinc-replete medium until differentiation. Zinc deprivation induced a decrease of transepithelial electrical resistance and alterations to tight and adherens junctions, with delocalization of zonula occludens (ZO-1), occludin, β-catenin, and E-cadherin. Disorganization of F-actin and β-tubulin was also found in zinc deficiency. These changes were associated with a loss of the amounts of ZO-1, occluding, and β-tubulin. In addition, zinc deficiency caused a dephosphorylation of occludin and hyperphosphorylation of β-catenin and ZO-1. Disruption of membrane barrier integrity led to increased migration of neutrophils. In addition, zinc deficiency induced an increase in the secretion of interleukin-8, epithelial neutrophil activating peptide-78, and growth-regulated oncogene-α, alterations that were not found when culture medium was replete with zinc. These results provide new information on the critical role played by dietary zinc in the maintenance of membrane barrier integrity and in controlling inflammatory cell infiltration.
i went looking for zinc influences on gliadin and filtered out the search term 'celiac'. what a funny twist this is:
Effects of zinc nutrition and high temperature on the growth, yield and grain quality of wheat (Triticum aestivum L.)
http://digital.library.adelaide.edu.au/ ... 2440/37982
"Electron microscopy confirmed this hypothesis, and showed that adequate Zn nutrition could maintain the integrity of a number of cellular membranes during high temperature, including the tonoplast, chloroplast envelope and the thylakoid membranes...
...results from both controlled environment and field experiments demonstrated that the detrimental effects of low Zn availability and high temperature on the yield of Zn inefficient or thermosensitive wheat varieties will be most damaging when these stresses occur in combination. Analysis of protein composition showed that supplementary Zn fertilisation increased the glutenin:gliadin ratio in the grain. This suggests that Zn fertilisation may improve the bread-making quality of wheat under conditions of Zn deficiency."
i never thought it was the WHEAT that was zinc deficient. LOL!
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