Luongo wrote:Can anyone explain to a terribly impatient plebian like myself why for the last X amount of years there seem to be studies every 5 months or so about remyelination, usually peppered with hope-raising language like 'groundbreaking' and 'promising' and none of it ever seems to amount to anything?
lyndacarol wrote:... Why are researchers convinced that the symptoms in MS are due to these scars, and NOT due to a problem in the muscles themselves (such as insulin resistance inhibiting the energy source, glucose, from reaching the cell's mitochondria)?
I think researchers are looking in the wrong box of keys for THE key which will unlock this prison of MS.
http://www.vaccinex.comDr. Khan said only three molecules in the world, including this monoclonal antibody, are being investigated in patients with multiple sclerosis that focus on remyelination. “It is humbling to lead such a unique groundbreaking effort and that Wayne State University is one of the few centers in the world that are participating in this next true generation translational research,” he said. “ Funded by Vaccinex
MS is also believed to be an immune-mediated disorder and autoimmune T cells, in particular, have been implicated in destruction of normal neuronal tissue. In several different animal models of MS, we have shown that VX15/2503 is capable of blocking SEMA4D-induced activation of inflammatory cells and reducing the number of immune cells that accumulate abnormally in the brain and spinal cord during disease.
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