Niacin B3

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Re: Niacin B3

Postby jimmylegs » Fri May 16, 2014 4:19 pm

odd, i would have though ffa status would be positively correlated with the strength of the flush.

A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia
http://www.sciencedirect.com/science/article/pii/

Relationship between the niacin skin flush response and essential fatty acids in schizophrenia
http://www.sciencedirect.com/science/ar ... 7803001650

Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover
http://europepmc.org/abstract/MED/11695 ... jjQa5Th.24
"The n-3 essential fatty acid eicosapentaenoic acid (EPA) was added to the conventional antidepressant treatment of a treatment-resistant severely depressed and suicidal male patient with a seven-year history of unremitting depressive symptoms. The niacin skin flush test and cerebral magnetic resonance scanning were carried out at baseline and nine months later. The addition of ethyl-EPA led to a dramatic and sustained clinical improvement in all the symptoms of depression, including a cessation of previously unremitting severe suicidal ideation, within one month. Symptoms of social phobia also improved dramatically. During the nine-month period the volumetric niacin response increased by 30%..."
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Re: Niacin B3

Postby zjac020 » Sat May 17, 2014 1:04 am

way out of my league jimmy...now im completely lost
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Re: Niacin B3

Postby jimmylegs » Sat May 17, 2014 6:45 am

just responding to thx's point 2
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Re: Niacin B3

Postby THX1138 » Sat May 17, 2014 9:38 am

jimmylegs wrote:odd, i would have though ffa status would be positively correlated with the strength of the flush.

A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia
http://www.sciencedirect.com/science/article/pii/

Relationship between the niacin skin flush response and essential fatty acids in schizophrenia
http://www.sciencedirect.com/science/ar ... 7803001650

Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover
http://europepmc.org/abstract/MED/11695 ... jjQa5Th.24
"The n-3 essential fatty acid eicosapentaenoic acid (EPA) was added to the conventional antidepressant treatment of a treatment-resistant severely depressed and suicidal male patient with a seven-year history of unremitting depressive symptoms. The niacin skin flush test and cerebral magnetic resonance scanning were carried out at baseline and nine months later. The addition of ethyl-EPA led to a dramatic and sustained clinical improvement in all the symptoms of depression, including a cessation of previously unremitting severe suicidal ideation, within one month. Symptoms of social phobia also improved dramatically. During the nine-month period the volumetric niacin response increased by 30%..."


Thanks JL. :-D I just amended that post.
Below is part of what I was talking about:
The circadian rhythm of iMg2+ was found to be considerably more pronounced than that of total Mg and was negatively correlated to changes of free fatty acids.
http://www.ncbi.nlm.nih.gov/pubmed/7578617
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Re: Niacin B3

Postby jimmylegs » Sat May 17, 2014 10:23 am

ok so the inverse correlation is between variation in circadian rhythm, and 'changes' of free fatty acid. i would definitely need to see full text to get a real handle on what that sentence is actually saying!
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Re: Niacin B3

Postby Scott1 » Sat May 17, 2014 3:03 pm

This is a good discussion but if we go back to the original proposition aren't you just trying to improve vasodilation?

I would use L-arginine to dilate the blood vessels and coenzyeme Q10 to improve the quality of the blood cells. That would be part of a bigger protocol which I have set out here - regimens-f22/topic24019.html

The Niacin seems like using a hammer to open screwtop jars to me. It just depends how many jars you have.
The fumurate esters are interesting but if you go back a step you will be looking at arginine so why not start there?

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Re: Niacin B3

Postby jimmylegs » Sat May 17, 2014 3:43 pm

i personally used niacin early on, to improve blood flow for better oxygen and nutrient delivery. it was a factor in the klenner protocol for ms which did me so much good. for years upon years prior to dx, as a vegan, i would not necessarily have had the best niacin status. so in the early days it made sense. but i switched to omnivore basically a few minutes after getting diagnosed. now i'm pretty sure i have plenty in my system. http://www.whfoods.com/genpage.php?tnam ... #foodchart
i have read that the concerns over supplemental niacin's potential damage to the liver are exaggerated, but personally, it's still not something i would bother taking as a long term thing.
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Re: Niacin B3

Postby nbritton » Sat Jan 02, 2016 7:22 pm

marcopolo wrote:From what I have read b6 and b12 metabolize homocystine along with folic acid. Not prepared to give up my 'high' albeit brief
but you got to ask yourself why is that. Again it goes along way to support the cardio vascular nature of the disease.

Someday soon someone's going to wake up and the lights going to go on and we'll all be better off because of it.


I'm betting the reason why niacin increases homocysteine is that it slows down the conversion of homocysteine into methionine via MTRR. An alternate conversation process is via BHMT, so taking betaine (A/K/A trimethylglycine or TMG) should increase the conversion rate and ultimately reduce homocysteine. Also increasing your intake of methylfolate (folate) and/or methylcobalamin (B12) should also reduce homocysteine levels. Pyridoxine (B6) can also reduce homocysteine by converting it into cystathionine via CBS.

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Re: Niacin B3

Postby David1949 » Sun Jan 03, 2016 3:57 pm

For the benefit of anyone planning to try Niacin I should point out that the "flush" feels like your skin is on fire. So I would suggest starting with a low dose and gradually working up. Also be ready to jump into a cold shower if you do happen to O.D.
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Re: Niacin B3

Postby CureOrBust » Sun Jan 03, 2016 5:07 pm

David1949 wrote:For the benefit of anyone planning to try Niacin I should point out that the "flush" feels like your skin is on fire. So I would suggest starting with a low dose and gradually working up. Also be ready to jump into a cold shower if you do happen to O.D.
Apart from feeling like its "on fire" you will also get an itch that will drive you crazy! I have never tried a cold shower, but I have noticed in winter, after the flush has finished, if I have a hot/warm shower, the itch goes into overdrive. One thing I have done often in the past which appears to lower the intensity of the flushing, is making sure I am fully covered/rugged up BEFORE and during the dose. Sounds counter-intuitive, but it appears to help me.
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