jimmylegs wrote:odd, i would have though ffa status would be positively correlated with the strength of the flush.
A volumetric biochemical niacin flush-based index that noninvasively detects fatty acid deficiency in schizophrenia
Relationship between the niacin skin flush response and essential fatty acids in schizophrenia
http://www.sciencedirect.com/science/ar ... 7803001650
Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover
http://europepmc.org/abstract/MED/11695 ... jjQa5Th.24
"The n-3 essential fatty acid eicosapentaenoic acid (EPA) was added to the conventional antidepressant treatment of a treatment-resistant severely depressed and suicidal male patient with a seven-year history of unremitting depressive symptoms. The niacin skin flush test and cerebral magnetic resonance scanning were carried out at baseline and nine months later. The addition of ethyl-EPA led to a dramatic and sustained clinical improvement in all the symptoms of depression, including a cessation of previously unremitting severe suicidal ideation, within one month. Symptoms of social phobia also improved dramatically. During the nine-month period the volumetric niacin response increased by 30%..."
http://www.ncbi.nlm.nih.gov/pubmed/7578617The circadian rhythm of iMg2+ was found to be considerably more pronounced than that of total Mg and was negatively correlated to changes of free fatty acids.
marcopolo wrote:From what I have read b6 and b12 metabolize homocystine along with folic acid. Not prepared to give up my 'high' albeit brief
but you got to ask yourself why is that. Again it goes along way to support the cardio vascular nature of the disease.
Someday soon someone's going to wake up and the lights going to go on and we'll all be better off because of it.
Apart from feeling like its "on fire" you will also get an itch that will drive you crazy! I have never tried a cold shower, but I have noticed in winter, after the flush has finished, if I have a hot/warm shower, the itch goes into overdrive. One thing I have done often in the past which appears to lower the intensity of the flushing, is making sure I am fully covered/rugged up BEFORE and during the dose. Sounds counter-intuitive, but it appears to help me.David1949 wrote:For the benefit of anyone planning to try Niacin I should point out that the "flush" feels like your skin is on fire. So I would suggest starting with a low dose and gradually working up. Also be ready to jump into a cold shower if you do happen to O.D.
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