leonardo wrote:I think that all supplements that stimulate immune system are by default not recommended for msers. I don't like this approach because we some of them may turn out good for ms.
Agreed. I think the issue is if you stimulate your immune system in terms of increasing your B cells in particular then by default you are increasing levels of EBV. I think that is why MS therapies are somewhat effective, they target B cells and keep their levels low.
If we can keep our EBV levels low we may be able to control our MS. This is easier said than done as EBV is elusive and we don’t really know exactly how it switches from Latent to Reactivation. Being that EBV lives in our B cells which are a part of our immune system It is safe to say that keeping your immune system from flaring up will help. So keep as healthy as possible. Following these guidelines may help…
-Wash your hands, don’t touch your face (serious, see next point)
-Avoid infections (one suspected trigger for EBV is unrelated infections, B-cell receptor stimulation triggers reactivation in B-cell lines including those infected with EBV)
-keep excellent dental hygiene (most infections take place in the gums)
-Keep Vit D levels high (drink lots of water as you can develop kidney stones)
-Keep Uric Acid levels high with Inosine (drink lots of water as you can develop kidney stones)
-Exercise (focus on strength/muscle building)
-Keep vitamins and minerals optimal through blood tests (zinc lozenges seem particularly helpful in combating EBV)
-Avoid stress as much as is practical (I have a very stressful job but employ various techniques to keep it in check)
-Drink only in moderation
-Avoid Dairy (see link below)
-Get adequate sleep (another one I am guilty of breaking)
-Eat Swank or at least a low fat diet (low fat is recommended for people with mono, the initial active form of EBV which occurs in less than 50% of infected)
-Take a DMD if above doesn't suffice as they reduce overall B cell numbers.
Avoiding Dairy is not something I believed in until I came across this info...
The EBV lytic cycle is induced in cell culture by various stimuli, including sodium butyrate. Butyrate is a saturated short-chain fatty acid (SCFA) found primarily in cheese and other dairy products. It is also found in high quantities in Kombucha tea. While this tea has numerous other benefits being packed with anti-oxidants it definitely has high Butyrate. Interestingly another SCFA fatty acid ,which is not saturated, blocks the EBV reactivation actions of Butyrate. This is likely due to it using the same uptake pathways and enzymes which blocks butyrate. The fatty acid is Valproic and is used medically to treat patients with epilepsy and manic disorders occurring naturally in berries. Raspberries, Blueberries and Strawberries all possess high amounts of Valproic acid.
It is unknown how Butyrate promotes lytic activation and why it has differing effects on EBV reactivation than Valproic acid. I think this is due to the saturation of Butyrate and is yet another justification for the avoidance of Saturated fats. http://fundedresearch.cancer.gov/ncipor ... sessionid=
Effects of short-chain fatty acids on Epstein-Barr virus in B cell lymphoma “…The EBV lytic cycle is induced in cell culture by various stimuli, including sodium butyrate. Butyrate is a short-chain fatty acid (SCFA)…” http://www.ncbi.nlm.nih.gov/pubmed/15047835
Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression. http://www.ncbi.nlm.nih.gov/pubmed/6257378
Effect of short-chain fatty acids on Epstein-Barr virus early and viral capsid antigen induction in P3HR-1 cells http://link.springer.com/article/10.1007%2FBF01310678
Quantitative analysis of the Epstein-Barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria http://wholefoodcatalog.info/nutrient/b ... ds/high/1/
Foods containing Butyrate http://en.wikipedia.org/wiki/Valproic_acid http://en.wikipedia.org/wiki/Butyric_acid
More fuel for the EBV fire...
305 MS patients were tested and ALL had EBV, and the levels of EBV were significantly higher than controls. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089959/
EBV levels are higher in MS patients during relapses. http://www.healthline.com/health-news/m ... -between-m
The only proven MS cure is to destroy your immune system and build it back with stem cells. Which would also kill all EBV.http://www.sciencedaily.com/releases/20 ... 121738.htm
Good old Swank diet’s efficacy could be tied to the fact that the Lytic replication of EBV requires Fatty Acids. By restricting them we are restricting its ability to multiply in our body. http://www.ncbi.nlm.nih.gov/pubmed/15047835
[i] "...These results suggest that cellular Fatty Acid Synthase (FAS) activity is important for induction of Z transcription from the intact latent EBV genome, perhaps reflecting the involvement of lipid-derived signaling pathways or palmitoylated proteins. Furthermore, using FAS inhibitors may be a completely novel approach for blocking the lytic form of EBV replication..." [i]
Vitamin D also acts directly on EBV. http://www.ncbi.nlm.nih.gov/pubmed/17574770
Stress is often blamed for increasing risk of relapse. Stress is directly tied to higher EBV levels, even in healthy controls. http://www.ncbi.nlm.nih.gov/pubmed/7991763