New neuroprotection compound - hope for Progressive MS?

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New neuroprotection compound - hope for Progressive MS?

Postby MSUK » Fri Nov 22, 2013 4:42 am

New neuroprotection compound brings possibility of stopping MS disease progression

A $500,000 drug development grant from the National Multiple Sclerosis Society (NMSS) was awarded to a partnership between a multiple sclerosis research team at the Icahn School of Medicine at Mount Sinai and Karyopharm Therapeutics Inc., a clinical stage pharmaceutical company. Dr. Patrizia Casaccia, MD, PhD, Professor in the Departments of Neuroscience and Genetics and Genomics, at Icahn School of Medicine at Mount Sinai, will be the academic lead. She will test the effectiveness of a novel Karyopharm compound that can be orally administered and aimed at stopping the progressive phase of the disease. With the 14-month grant, Dr. Casaccia also hopes to gather information that will help design future clinical trials for MS treatments......... Read More - http://www.ms-uk.org/nervecells
MS-UK - http://www.ms-uk.org/
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Re: New neuroprotection compound - hope for Progressive MS?

Postby HarryZ » Sun Nov 24, 2013 8:46 am

In mouse models, oral administration of the new compound to mice with paralysis of the tail and hindlimb, allowed them to walk again.


I was actually quite interested until I got to this section of the report. I've lost count of the number of early treatment discoveries that have stopped and reversed the disease process in that poor MS mouse. I really hope that the outcome of this discovery will be different but I won't hold my breath.
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Re: New neuroprotection compound - hope for Progressive MS?

Postby LR1234 » Mon Nov 25, 2013 8:20 am

We can hope though Harry.....one day they gotta hit on something!! Or maybe not ;) x
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Re: New neuroprotection compound - hope for Progressive MS?

Postby tzootsi » Mon Nov 25, 2013 8:32 am

Dr Casaccia gave a very interesting lecture last year. First time I've heard a neurologist recommending things like gluten avoidence and diet.

http://www.youtube.com/watch?v=3xnFNzflLWU
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Re: New neuroprotection compound - hope for Progressive MS?

Postby HarryZ » Mon Nov 25, 2013 8:46 am

LR1234 wrote:We can hope though Harry.....one day they gotta hit on something!! Or maybe not ;) x


Yes, we certainly can! A number of years ago the neuro at the MS Clinic my wife went to, told her that the cure would likely be something that a researcher would stumble upon by accident. I've been waiting for this accident to happen for a long time!

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Re: New neuroprotection compound - hope for Progressive MS?

Postby HarryZ » Mon Nov 25, 2013 8:49 am

tzootsi wrote:Dr Casaccia gave a very interesting lecture last year. First time I've heard a neurologist recommending things like gluten avoidence and diet.

http://www.youtube.com/watch?v=3xnFNzflLWU


Neuros, for the most part, can be a very narrow sighted group when it comes to MS treatment. There are, as you have discovered, some who open their blinders and see that there are other avenues available that work for many patients.

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