Looking at brain tissue loss, or gray matter atrophy, is quickly becoming the new way to measure MS disease progression.
Grey matter atrophy occurs in the earliest stages of MS, progresses faster than in healthy individuals, and shows significant correlations with MRI lesion load, cognitive function and measures of physical disability; indeed, brain atrophy is the best predictor of subsequent disability and can be readily measured using MRI.
That said, disease modifying medicines were created to limit white matter lesions and relapses, not stop loss of gray matter, or what is called "neurodegeneration." So now, researchers are looking and trying to figure out how these medications are affecting the whole brain, not just white matter. And there's lots of conflicting info.
Some researchers think the brain tissue loss on beta interferons is "pseudo atrophy"--or a false loss of tissue which is only temporary.
During the first months of treatment, many DMTs produce an apparent increase in atrophy rate (pseudoatrophy), probably due to a loss of intracellular water as a result of their anti-inflammatory activity.
The truth is, we really don't know how the drugs affect gray matter, because it is only now being studied.
So, what can you do to prevent gray matter loss?
There's actually a lot you can do with lifestyle, nutrition, and exercise to keep your gray matter.
Here's a list of ideas to consider, to keep your gray matter healthy. Hope it helps!https://www.facebook.com/notes/ccsvi-in ... 1434857211