The gut is important, but so is the blood brain barrier--and they are related.
Both are protected by endothelial cells, which maintain the permeability and tight junctions of blood vessels, and either allow or block access of plasmic particles and antigens into tissue.
Endothelial cells are affected by hundreds of outside, or environmental, factors--including, but not limited to:
zonulin (protein found in gluten), viruses and bacteria, hormones (such as vitamin D, estrogen, cortisol), exercise (which creates shear stress and promotes tight junctions), UV rays (via nitric oxide release), heavy metals and toxins, trans and saturated fats, glucose, smoking, oxidative stress.
If we look at MS as a disease of endothelial dysfunction and permeability, we can see how all of the environmental factors shown to be related to MS susceptibility and progression--UV rays, latitude, stress, smoking, EBV, cpn, various bacteria--are multi-factorial components which compound endothelial dysfunction.
MS may turn out to be a combo-platter of environmental and genetic components lining up, allowing permeability of the blood brain barrier-- access of the immune system, fibrinogen, and plasmic particles into brain tissue, which begin an inflammatory cycle in those with a genetic susceptability.
Heal the endothelium, heal the gut, heal the blood brain barrier.
This approach has worked for my husband, now 7 years past diagnosis, no MS progression, no further lesions, a reversal in gray matter atrophy (shown on MRI) and reversal of disability.http://ccsvi.org/index.php/helping-myse ... ial-health
Thankful for the ISNVD--a group of researchers exploring and publishing on endothelial dysfunction in MS and neurological disease. http://www.ncbi.nlm.nih.gov/pubmed/24228622