Thanks for the link, questor. The doctor didn't link any research to back up his claims, so I wanted to dig deeper into EGCG, since that's been a mainstay of Jeff's regimen for several years now.
There are nine anecdotal reports of liver toxicity in humans, potentially related to EGCG consumption.
Studies in mice orally administered 1500mg (!!!) created oxidative stress and hepatoxicityhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905152/
But in humans, EGCG has been shown in studies to prevent liver disease, act as a neuroprotective agent, and a chelator of heavy metals from the brain. http://www.ncbi.nlm.nih.gov/pubmed/19756809http://forschungsberichte.charite.de/FO ... 28373.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/17447435
Here's a recent review of EGCG as a potential treatment in neurological disease:http://www.epmajournal.com/content/4/1/5
It was the Charite (Berlin) EGCG studies in MS that prompted my interest. They administered 400mg daily doses of Sunphenon http://www.sunphenon.com/products-containing-sunphenon/http://clinicaltrials.gov/ct2/show/NCT00525668
(Results have not been published.)
There are some cases of toxicity and liver failure in the published literature---http://onlinelibrary.wiley.com/doi/10.1 ... 21021/full
The mechanism of the toxicity of green tea extract is unclear. A study looking into the cytotoxicity of green tea extract on rat hepatocytes was unable to determine whether EGCG has toxic effects at plasma levels considerably higher than those achieved in human pharmacokinetic studies.13 Therefore, the possibility of an allergic reaction to the green tea itself—or, more likely, a component of the extract—or contamination during the growth of the leaves or during production of the extract has also been suggested. It is extremely unlikely that the modest weight loss induced by the green tea extracts plays a role in causing severe hepatotoxicity.
Most of the cases I found, like this woman, are people who are overweight and are taking a "fat burning" product. Which is this one case contained-
She was taking 7 capsules per day.
Green tea extract 120, Vitamin E 6, Wheat germ oil 10, Excipients in each capsule, Soy oil 154, Beeswax 13
Glycerol esters of fatty acids 13
Composition of the capsule
Moderation and making sure your product is of the highest quality is probably wise.
Consumption of between 700 and 2,000 milligrams per day led to toxic liver effects in nine anecdotal case reports, according to an article published by researchers from Rutgers, the State University of New Jersey in the March 2007 issue of “Chemical Research and Toxicology.”
“People who take less than 500 mg [of green tea concentrate or preparation] per day and spread the dose out over the course of the day are unlikely to have toxic side effects,” says Yang.
hope this info helps,