Could hypertension drug stimulate repair in MS?

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Could hypertension drug stimulate repair in MS?

Postby MSUK » Tue Jan 28, 2014 8:11 am

Could hypertension drug stimulate repair in Multiple Sclerosis?

Quite often, the development of novel therapies for one disease indication later gives rise to its application for other diseases as well. In the case of Multiple Sclerosis treatment, the non-profit Myelin Repair Foundation (MRF) may have identified a proven drug for hypertension that could be used to stimulate repair and protect the brain in MS patients.......... Read More - http://www.ms-uk.org/emergingtherapies
MS-UK - http://www.ms-uk.org/
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Re: Could hypertension drug stimulate repair in MS?

Postby Anonymoose » Tue Jan 28, 2014 8:41 am

Based on my experience with trying an anti-hypertensive (did help with symptoms), I'd say it better be a really low dose for those of us with normal or low bp. Wonder what it is.
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Re: Could hypertension drug stimulate repair in MS?

Postby tzootsi » Tue Jan 28, 2014 3:37 pm

What is MRF-008? Myelin Repair Foundation's substance #8? Could it be Lisinopril which is used for treating hypertension and has been looked at as a treatment for MS?
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Re: Could hypertension drug stimulate repair in MS?

Postby cheerleader » Tue Jan 28, 2014 3:50 pm

tzootsi wrote:What is MRF-008? Myelin Repair Foundation's substance #8? Could it be Lisinopril which is used for treating hypertension and has been looked at as a treatment for MS?


Yup. You got it tzootsi! Looks like Steinman's research, which was funded by the NIH, who then went to MRF for funding and help with the clinical trial. Now, they'll take an inexpensive bp drug, repackage it, and charge $40,000 a year to pwMS. Lisinopril is the generic name for the medicine, and it costs maybe a couple $100 a year. http://www.myelinrepair.org/mrf-008.sht ... dium=email
http://www.examiner.com/article/lisinop ... -sclerosis

I've written about lisinopril a bunch. It reverses endothelial dysfunction (not any better than diet and exercise, but hey, it's a pill.)
Here's more info for those interested in this new "neuroprotective" model of drugs for MS--addressing cerebral blood flow, not the immune system.

Lisinopril is--

An inexpensive blood pressure medication and ACE inhibitor which modulates angiotensin. This drug opens up blood vessels and allows blood to flow more easily. This older drug is being developed to treat MS by Dr. Lawrence Steinman of Stanford University School of Medicine. (Dr. Steinman is also one of the inventors of Tysabri--which he has since spoken out against as a first line treatment for MS.)

... angiotensin immediately causes blood vessels to constrict. “That raises your blood pressure so when you stand up to get out of a chair, you don’t fall down and faint,” said Steinman, who is also the George A. Zimmerman Professor in the medical school. But angiotensin overactivity causes chronic hypertension. Lisinopril controls blood pressure by blocking an enzyme that converts angiotensin’s precursor into the active hormone. The drug also appears to have certain anti-inflammatory properties.
http://med.stanford.edu/ism/2009/august/lisinopril.html


http://ccsviinms.blogspot.com/2013/08/m ... blood.html

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Could hypertension drug stimulate repair in MS?

Postby Azaeleaprawn » Sat Feb 01, 2014 10:26 pm

A while ago I read somewhere that the hypertension drug Captopril helped - wonder if it's the one.
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Re: Could hypertension drug stimulate repair in MS?

Postby jackD » Sun Feb 02, 2014 12:06 pm

Azaeleaprawn wrote:A while ago I read somewhere that the hypertension drug Captopril helped - wonder if it's the one.


I made a post in the GENERAL MEDICATION section on the "other" GOOD effects of some Blood Pressure drugs.

http://www.thisisms.com/forum/general-medications-f42/topic18958.html

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Re: Could hypertension drug stimulate repair in MS?

Postby msmything » Tue Mar 18, 2014 6:44 pm

All of this is back up in the press..I just got an e-mail from the myelin repair foundation requesting funding to help with the joint trial with the NIH. They sure are keeping the name of the drug in question under wraps.

Do you folks still think it's Lisinopril?

Colleen
Be kinder than necessary, for everyone you meet is fighting some kind of battle..
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Re: Could hypertension drug stimulate repair in MS?

Postby Scott1 » Wed Mar 19, 2014 1:34 am

I know a lot of you want a pill to do the work but L-arginine will do just as good a job. Get an amino acid test done and look at your current level of arginine vs the normal range. I'll let the numbers do the talking.

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