jerrygallow wrote:is there any basis to think this may work, or is it a shot in the dark?
It looks like a shot in the dark, based on preliminary result of a "novel high-throughput screening program aimed at identifying compounds that would promote oligodendrocyte-driven myelinating activity", accomplished via cell assay as opposed to in situ analysis.
Further, the article linked above contains a warning:
"By the way, if you're an MS patient, or a clinician thinking about suggesting clemastine to patients, know this: other than the high-throughput screen result in a cell culture assay, there is not one iota of evidence that the drug has any benefit in MS. No epidemiological studies, no case reports, no animal research, nada".
I think it is too soon to take personal action, but, it is good to see that studies of this kind are underway, and the antihistamine aspect is intriguing (although opposite to the conclusions that gave rise to the formulated histamine medication prokarin: http://en.wikipedia.org/wiki/Prokarin