MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

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MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby seeva » Tue Feb 18, 2014 5:03 am

HI FRIENDAS A Phase1 trails of a new treatment to reset the immune system of m.s patients shows the therapy is safe and highly effective.
please read more http://www.healthline.com/health-news/m ... cks-060513
regard
seeva
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby HarryZ » Tue Feb 18, 2014 6:39 am

seeva wrote:HI FRIENDAS A Phase1 trails of a new treatment to reset the immune system of m.s patients shows the therapy is safe and highly effective.
please read more http://www.healthline.com/health-news/m ... cks-060513
regard
seeva


I've said it before many times...nobody has been able to prove that MS is an auto-immune disease and some researchers have stated they believe that the patient's immune system is only reacting to another unknown event which is triggering the immune system to respond in a normal manner.

Now if this procedure does indeed prevent the immune system from causing further damage to the MS patient that would be great. Whether it does anything to stop that initial attack process is unknown but at least the severity and number of attacks might be curtailed.

But you can expect our MS drug making companies not to sit idly by and have a process interfere with their cash cow. Certainly makes for interesting months ahead.

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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby centenarian100 » Tue Feb 18, 2014 6:28 pm

"The results showed that the therapy was safe and reduced the patients’ immune system attacks on myelin by as much as 50 to 75 percent."

This article is just painful to read. The article doesn't state the outcome measure. Are they referring to gad+ lesions, new/enlarging T2 lesions, clinical relapses? What do you mean by "as much as 50-75%"? What is the average size of effect?

If you have one patient that had no relapses, you can call it "as much as 100% reduction in relapses"

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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby HarryZ » Tue Feb 18, 2014 8:39 pm

centenarian100 wrote:"The results showed that the therapy was safe and reduced the patients’ immune system attacks on myelin by as much as 50 to 75 percent."

This article is just painful to read. The article doesn't state the outcome measure. Are they referring to gad+ lesions, new/enlarging T2 lesions, clinical relapses? What do you mean by "as much as 50-75%"? What is the average size of effect?

If you have one patient that had no relapses, you can call it "as much as 100% reduction in relapses"

Sheesh


Phase 1 and 2 studies more often than not don't give a lot of detailed information. They are mostly done to test for side effects and ensure that patients can tolerate the medication. The nitty gritty numbers come with Phase 3 trials. And those usually take 2 years to complete after being approved to start.
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby centenarian100 » Tue Feb 18, 2014 9:38 pm

HarryZ wrote:Phase 1 and 2 studies more often than not don't give a lot of detailed information. They are mostly done to test for side effects and ensure that patients can tolerate the medication. The nitty gritty numbers come with Phase 3 trials. And those usually take 2 years to complete after being approved to start.


Phase 1 studies are mainly for safety, but the article makes claims about efficacy, and if they are going to make such claims, they should state the data explicitly.
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby PointsNorth » Tue Feb 18, 2014 9:41 pm

centenarian100 wrote:"The results showed that the therapy was safe and reduced the patients’ immune system attacks on myelin by as much as 50 to 75 percent."

This article is just painful to read. The article doesn't state the outcome measure. Are they referring to gad+ lesions, new/enlarging T2 lesions, clinical relapses? What do you mean by "as much as 50-75%"? What is the average size of effect?

If you have one patient that had no relapses, you can call it "as much as 100% reduction in relapses"

Sheesh


Required reading for Big Pharma execs: http://en.wikipedia.org/wiki/How_to_Lie_with_Statistics :-|
Albany 2010. Brooklyn 2011
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby centenarian100 » Tue Feb 18, 2014 9:52 pm

PointsNorth wrote:Required reading for Big Pharma execs: http://en.wikipedia.org/wiki/How_to_Lie_with_Statistics :-|


Haha

nice username by the way
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby HarryZ » Wed Feb 19, 2014 5:29 am

Phase 1 studies are mainly for safety, but the article makes claims about efficacy, and if they are going to make such claims, they should state the data explicitly.


It's called throwing out a carrot to the public in order to create interest!!

Over the years I've attended presentations sponsored by the MS drug makers where they brought out the fancy stat charts to show how wonderful their medication was helping MS patients. When you sifted through all the rhetoric, you soon realized the slick marketing behind it all.
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby centenarian100 » Sun Feb 23, 2014 10:06 pm

HarryZ wrote:It's called throwing out a carrot to the public in order to create interest!!

Over the years I've attended presentations sponsored by the MS drug makers where they brought out the fancy stat charts to show how wonderful their medication was helping MS patients. When you sifted through all the rhetoric, you soon realized the slick marketing behind it all.


Marketing works. They actually convinced me that I need a shiny rock to be happy. :lol:
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Re: MS BREAKTHROUGH RESET PATIENTS' IMMUNE SYSTEMS

Postby HarryZ » Mon Feb 24, 2014 7:12 am

centenarian100 wrote:
HarryZ wrote:It's called throwing out a carrot to the public in order to create interest!!

Over the years I've attended presentations sponsored by the MS drug makers where they brought out the fancy stat charts to show how wonderful their medication was helping MS patients. When you sifted through all the rhetoric, you soon realized the slick marketing behind it all.


Marketing works. They actually convinced me that I need a shiny rock to be happy. :lol:


There you go!!! Just don't give any of those CRAB drugs to that nice rock :lol:
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