Bottom line is that it is good to see some brain-stretching in this area.
Anecdote wrote:One of the authors is MH Barnett of Prineas and Barnett fame. He must have been thinking along these lines for quite some time.
neurodegeneration appears to be at least partially independent from neuroinflammation….. It is likely that immunomodulatory treatments acting purely in the periphery will provide only indirect and not direct neuroprotection…
The pathogenic process in the central nervous system itself should be the major focus in multiple sclerosis therapy in order to protect against demyelination and axonal loss and to promote remyelination and regeneration directly in the target tissue, independently of peripheral immune status. In conclusion, selective treatment strategies aimed at preventing axonal injury within the central nervous system are required to complement existing, peripherally acting treatments targeting the immune system.
Oligodendrocytes are known to express (Ca2+)-permeable glutamate receptors and to have low resistance to oxidative stress, two factors that make them potentially susceptible to injury…….Previous studies had failed to detect NMDA receptor mRNA or current in oligodendrocytes but three new papers demonstrate NMDA receptor expression in oligodendrocytes.
that people with MS have fewer clinically evident infections than controls and that people with more infections seem to progress more slowly (opposite to what you would expect).
Furthermore, BDNF is expressed in different types of inflammatory cells in brain lesions of patients with acute disseminated leukoencephalopathy or multiple sclerosis. It seems plausible that the immune cell-mediated import of BDNF and other neurotrophic factors into the central nervous system has functional consequences and implications for the therapy of multiple sclerosis and other neuroimmunological diseases.
an important paradigmatic shift in the study of MS has occurred in the past decade. It is now clear that MS is not just a disease of the immune system, but that factors contributed by the central nervous system are equally important and must be considered in the future.
HarryZ wrote:... he did that autopsy a couple of years ago on the 17 year old girl who died suddenly from a massive exacerbation ...
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