fatboislim wrote:Statin Therapy Inhibits Remyelination in the Central Nervous System
The American Journal of Pathology, Vol. 174, No. 5, May 2009
Together, our data support the conclusion that simvastatin blocks the differentiation of progenitors into mature myelinating cells, thereby inhibiting remyelination in the cuprizone model. We also show the importance of cholesterol and isoprenoid synthesis pathways in processes of myelin maintenance and remyelination. Our findings also highlight the necessity of monitoring long-term effects of systemically applied therapies that can access the CNS, particularly those that can impact cell types that are postulated to be targeted in neurological disease processes and that are implicated in any tissue repair process. The expression of the enzyme inhibited by statins, HMG Co-A reductase, in all cell types along with the penetration of the lipophilic simvastatin into the brain parenchyma, together suggest potential direct effects of statins on neural cell properties.
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