Could statins slow progressive multiple sclerosis?

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Could statins slow progressive multiple sclerosis?

Postby MSUK » Wed Mar 19, 2014 1:06 am

As well as lowering cholesterol and cutting stroke risk, statins may slow the progression of advanced multiple sclerosis.<br><br>

Globally, 2.5 million people have MS. Of these, two-thirds will develop the advanced form of the disease within 15 years of diagnosis. Although several treatments exist for the early phase of the disease – called relapsing-remitting MS – there is no treatment for the more advanced phase, called secondary progressive MS (SPMS)..... Read More - http://www.ms-uk.org/statins
MS-UK - http://www.ms-uk.org/
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Re: Could statins slow progressive multiple sclerosis?

Postby Leonard » Wed Mar 19, 2014 5:53 am

Could statins slow progressive multiple sclerosis?

the answer is yes.
the recent Buffalo study shows the effect of the fat metabolism on the lesions.
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Re: Could statins slow progressive multiple sclerosis?

Postby fatboislim » Sat Apr 05, 2014 6:34 pm

Statin Therapy Inhibits Remyelination in the Central Nervous System
Neurobiology
The American Journal of Pathology, Vol. 174, No. 5, May 2009

Conclusion
Together, our data support the conclusion that simvastatin blocks the differentiation of progenitors into mature myelinating cells, thereby inhibiting remyelination in the cuprizone model. We also show the importance of cholesterol and isoprenoid synthesis pathways in processes of myelin maintenance and remyelination. Our findings also highlight the necessity of monitoring long-term effects of systemically applied therapies that can access the CNS, particularly those that can impact cell types that are postulated to be targeted in neurological disease processes and that are implicated in any tissue repair process. The expression of the enzyme inhibited by statins, HMG Co-A reductase, in all cell types along with the penetration of the lipophilic simvastatin into the brain parenchyma, together suggest potential direct effects of statins on neural cell properties.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671276/pdf/JPATH174001880.pdf
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Re: Could statins slow progressive multiple sclerosis?

Postby lyndacarol » Sat Apr 05, 2014 6:45 pm

fatboislim wrote:Statin Therapy Inhibits Remyelination in the Central Nervous System
Neurobiology
The American Journal of Pathology, Vol. 174, No. 5, May 2009

Conclusion
Together, our data support the conclusion that simvastatin blocks the differentiation of progenitors into mature myelinating cells, thereby inhibiting remyelination in the cuprizone model. We also show the importance of cholesterol and isoprenoid synthesis pathways in processes of myelin maintenance and remyelination. Our findings also highlight the necessity of monitoring long-term effects of systemically applied therapies that can access the CNS, particularly those that can impact cell types that are postulated to be targeted in neurological disease processes and that are implicated in any tissue repair process. The expression of the enzyme inhibited by statins, HMG Co-A reductase, in all cell types along with the penetration of the lipophilic simvastatin into the brain parenchyma, together suggest potential direct effects of statins on neural cell properties.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671276/pdf/JPATH174001880.pdf


Welcome to ThisIsMS, fatboislim.

Thank you for a very important and relevant post to this thread. We are glad to have you jump in with this contribution.
My hypothesis: excess insulin (hyperinsulinemia) plays a major role in MS, as developed in my initial post: http://www.thisisms.com/forum/general-discussion-f1/topic1878.html "Insulin – Could This Be the Key?"
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