I think the important thing is to restore your body's ability to metabolize vitamin B12.
Numerous studies have shown that MS patients lack vitamin B12 due to an inability to properly metabolize the vitamin. For instance, researchers in the following study found that MS patients had significantly lower vitamin B12 levels and concluded: “There is a significant association between MS and disturbed vitamin B12 metabolism.”
Vitamin B12 metabolism in multiple sclerosis.
Reynolds EH, Bottiglieri T, Laundy M, Crellin RF, Kirker SG. 1992. Arch Neurol.
“…Patients with MS had significantly lower serum vitamin B12 levels…than neurological and normal controls…There is a significant association between MS and disturbed vitamin B12 metabolism…The cause of the vitamin B12 disorder and the nature of the overlap with MS deserve further investigation.”
In the next study the researchers stated they suspected the vitamin B12 deficiency in MS may be due to problems with binding and/or transport. In addition, the researchers concluded that further studies of vitamin B12 metabolism, binding, and transport in MS are indicated, as they feel this may offer clues to the understanding of MS.
Multiple sclerosis associated with vitamin B12 deficiency.
Reynolds EH, Linnell JC, Faludy JE. 1991. Arch Neurol. 48(8):808-11.
“…A vitamin B12 binding and/or transport is suspected. The nature of the association of multiple sclerosis and vitamin B12 deficiency is unclear but is likely to be more than coincidental. Further studies of vitamin B12 metabolism, binding, and transport in multiple sclerosis are indicated, as these cases may offer a clue to the understanding of a still mysterious neurologic disorder.”
In the following study researchers also found that MS patients have a decrease in the binding capacity of vitamin B12, thus inhibiting the transport of vitamin B12 into the cells, even with normal levels in their blood.
Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis.
Kira J, Tobimatsu S, Goto I. 1994. Intern Med. 33(2):82-6.
“Serum vitamin B12 levels and unsaturated vitamin B12 binding capacities were measured in 24 patients with multiple sclerosis (MS), 73 patients with other neurological disorders and 21 healthy subjects. There was no decrease in the vitamin B12 levels, however, a significant decrease in the unsaturated vitamin B12 binding capacities was observed in patients with MS when compared with other groups…”
In the next study the researchers concluded their results suggested a “specific association” between the timing of onset of the first neurological symptoms of MS and vitamin B12 metabolism. The researchers also discussed the importance of vitamin B12 in the formation of myelin and stated that its deficiency in MS is of “critical pathogenetic significance.”
Vitamin B12 and its relationship to age of onset of multiple sclerosis.
Sandyk R, Awerbuch GI. 1993. Int J Neurosci. 71(1-4):93-9.
“these findings suggest a specific association between the timing of onset of first neurological symptoms of MS and vitamin B12 metabolism. In addition, since vitamin B12 is required for the formation of myelin and for immune mechanisms, we propose that its deficiency in MS is of critical pathogenetic significance.”
You could think of this like a break in a water pipe. You need to repair the pipe, not keep turning on the water valve. This just sends water where it shouldn't go.