The site you link is to a genetic study page, looking at S1PR2 in the rat genome...it won't really help us understand what's going on in humans in the MS study. I'll try to explain in simple terms--and include links.
It's important to understand WHY S1PR2 is in higher levels in the MS brain---learning how to block this receptor with an S1PR2 inhibitor may take many years. Doing something about lowering the levels through how we live our lives and our environment is something we can do today. We want to lower the amount of S1PR2, to strengthen the blood brain barrier, by making the endothelium (the lining of all of our blood vessels) stronger. http://www.eurekalert.org/pub_releases/ ... 050614.php
There are things we can change (environmental factors) and things we can't change (genetic factors) I like to look at the things we can change ourselves.
We're very fortunate, in that vascular researchers have been looking at the problem of higher levels of S1PR2 in inflammatory disease for many years. Neurology and immunology is just catching up in the study of the blood brain barrier.
In humans, S1PR2 shows up in higher than normal levels in people who are obese. Thin people do not have these high levels. What causes this to happen? Lower levels of oxygen are delivered to tissue, and this signals an increase in S1PR2 and creates inflammation. Losing weight is one way to lower the expression of S1PR2. This does NOT mean all people with MS are obese---it's just one of many environmental factors to consider. Something that can be changed is losing weight.http://www.ncbi.nlm.nih.gov/pubmed/24212262
There are many other ways to strengthen the endothelium yourself---while we wait for researchers to figure out how to inhibit the receptors which make the endothelium more permeable. Here is the program I created for my husband, to do this--based on research by an endothelial cardiovascular specialist at Stanford University.http://www.ccsvi.org/index.php/helping- ... ial-health
Hope this gives you more ideas on things you can do today to help yourself, while we wait for genetic interventions.