Could Dock3 protect against demyelination?

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Could Dock3 protect against demyelination?

Postby MSUK » Tue Sep 09, 2014 1:39 am

Dock3 protects myelin in the cuprizone model for demyelination.

Namekata K, Kimura A, Harada C, Yoshida H, Matsumoto Y, Harada T.

Abstract

Dedicator of cytokinesis 3 (Dock3) belongs to an atypical family of the guanine nucleotide exchange factors. It is predominantly expressed in the neural tissues and causes cellular morphological changes by activating the small GTPase Rac1.

We previously reported that Dock3 overexpression protects retinal ganglion cells from excitotoxic cell death. Oligodendrocytes are the myelinating cells of axons in the central nervous system and these cells are damaged in demyelinating disorders including multiple sclerosis (MS) and optic neuritis.

In this study, we examined if Dock3 is expressed in oligodendrocytes and if increasing Dock3 signals can suppress demyelination in a cuprizone-induced demyelination model, an animal model of MS.

We demonstrate that Dock3 is expressed in oligodendrocytes and Dock3 overexpression protects myelin in the corpus callosum following cuprizone treatment. Furthermore, we show that cuprizone demyelinates optic nerves and the extent of demyelination is ameliorated in mice overexpressing Dock3.

Cuprizone treatment impairs visual function, which was demonstrated by multifocal electroretinograms, an established non-invasive method, and Dock3 overexpression prevented this effect.

In mice overexpressing Dock3, Erk activation is increased, suggesting this may at least partly explain the observed protective effects.

Our findings suggest that Dock3 may be a therapeutic target for demyelinating disorders including optic neuritis.

Source: Cell Death and Disease (2014) 5, e1395; doi:10.1038/cddis.2014.357 & Pubmed PMID: 25165881 (09/11/14) http://www.ms-uk.org/nervecells
MS-UK - http://www.ms-uk.org/
User avatar
MSUK
Family Elder
 
Posts: 2903
Joined: Wed Oct 14, 2009 3:00 pm

Advertisement

Re: Could Dock3 protect against demyelination?

Postby CureOrBust » Tue Sep 09, 2014 4:03 am

MSUK wrote:... Dock3 overexpression protects myelin in the corpus callosum following cuprizone treatment. Furthermore, we show that cuprizone demyelinates optic nerves and the extent of demyelination is ameliorated in mice overexpressing Dock3.

Cuprizone treatment impairs visual function, which was demonstrated by multifocal electroretinograms, an established non-invasive method, and Dock3 overexpression prevented this effect. ...
Is it simply cost or do they specifically select a single disease model to perform test on which they think would best show the treatments success? ie why not try testing the substance on all MS mouse models?
User avatar
CureOrBust
Family Elder
 
Posts: 3347
Joined: Wed Jul 27, 2005 3:00 pm
Location: Sydney, Australia


Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service