Anti-Aging Molecule

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Anti-Aging Molecule

Postby dignan » Tue Jun 13, 2006 9:16 am

OK, this isn't MS-specific, but it sounds very interesting.



Anti-Aging Molecule Discovered

Korean Times - A team of South Korean scientists on Sunday claimed to have created a ``cellular fountain of youth,’’ or a small molecule, which enables human cells to avoid aging and dying.

The team, headed by Prof. Kim Tae-kook at the Korea Advanced Institute of Science and Technology, argued the newly-synthesized molecule, named CGK733, can even make cells younger.

The findings were featured by the Britain-based Nature Chemical Biology online early today and will be printed as a cover story in the journal’s offline edition early next month.

``All cells face an inevitable death as they age. On this path, cells became lethargic and in the end stop dividing but we witnessed that CGK733 can block the process,’’ Kim said.

``We also found the synthetic compound can reverse aging, by revitalizing already-lethargic cells. Theoretically, this can give youth to the elderly via rejuvenating cells,’’ the 41-year-old said.

Kim expected that the CGK733-empowered drugs that keep cells youthful far beyond their normal life span would be commercialized in less than 10 years.

Other researchers here heaped praises on the discovery but they were cautious about the practical therapeutic application of the new substance.

``Obviously, it is an innovative finding. But we need to see whether or not CGK733 could really rejuvenate cells inside human bodies without generating side effects,’’ Prof. Kim Sung-hoon at Seoul National University said.

Prof. Kim Tae-kook, however, is confident about the commercial viability of CGK733, believing the efficiency of the material was created using state-of-the-art magnetic nano-probe technology.

``We have the magnet-associated technology to identify molecular targets inside living cells, which allowed us to examine the mechanisms of CGK733 directly,’’ Kim said.

``Unlike other research teams that must make candidates materials for drugs without being able to see their intra-cell activities, we know the precise mechanism of CGK733. So we have the better chance of making a success of the substance,’’ he continued.

Indeed, Kim basked in global recognition last June when he and his associates developed a technology dubbed MAGIC, short for magnetism-based interactive capture.

MAGIC uses fluorescent materials to check whether any drug can mix with targeted proteins inside the cell. The results were globally recognized by being printed by the U.S.-based journal Science at the time.

``MAGIC is kind of a source technology to see inside cells. Based on the method, we also found a pair of promising substances that can deal with cancers,’’ Kim said.

http://times.hankooki.com/lpage/tech/20 ... 511780.htm
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dignan
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who pays

Postby gwa » Tue Jun 13, 2006 12:27 pm

If this hits the market, I bet the billionaires can afford it.

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anti-aging... eeek!

Postby jimmylegs » Tue Jun 13, 2006 2:00 pm

ya they better keep the price high until we find some more inhabitable planets, and ways to get to them ;)
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Postby viper498 » Wed Jun 14, 2006 6:43 am

Good point. Talk about overpopulation. I wonder if it really works, and I wonder if it would make you prone to certain diseases (like cancer)?
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Postby raven » Wed Jun 14, 2006 7:43 am

You nailed it Viper. The compound interferes with the ATM pathway. The ATM pathway is one of the mechanisms that checks for cell DNA damage. By blocking ATM you are effectively removing one of the quality control mechanisms that prevent cancerous cells.

The real find would be the ability to repair DNA damage rather than to remove the checking constraints.

But, anti-ageing is certainly coming and that raises huge ethical and moral questions.

Robin
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