could increase pain in spinal cord injury and worsen MS
A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period.
One implication is that if acrolein is exacerbating pain its concentration in the body could be reduced using the drug hydralazine, which has been approved by the U.S. Food and Drug Administration for hypertension, said Riyi Shi (pronounced Ree Shee), a professor in Purdue University's Department of Basic Medical Sciences, College of Veterinary Medicine, and Weldon School of Biomedical Engineering.......Read More - http://www.ms-uk.org/environmentalfactors
Toxin from tobacco smoke bad for MS....
Toxin from tobacco smoke bad for MS....
MS-UK - http://www.ms-uk.org/
Re: Toxin from tobacco smoke bad for MS....
Acrolein is a known carcinogen.
Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility
http://www.jbc.org/content/287/15/12379.full.pdf
Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility
http://www.jbc.org/content/287/15/12379.full.pdf
- Background: Acrolein is highly reactive and abundant in tobacco smoke.
- Results: Acrolein induces DNA damage, inhibits excision repair and mismatch repair, causes repair protein degradation, andenhances mutagenesis.
- Conclusion: Acrolein induces DNA damage and inhibits DNA repair that causes mutagenesis and initiates carcinogenesis.
- Significance: This is the first demonstration that acrolein inhibits DNA repair pathways by induction of repair protein degradation.