hey there cure, i went looking for nutrition and blood brain barrier on seeing your post and it came back to uric acid. the abstract below is probably posted elsewhere in the forums but since it directly goes to your bbb comment...
can't recall if you read/commented on the earlier uric acid posts where uric acid was mentioned in abstracts as a peroxynitrite scavenger, and that by supplementing with inosine, serum uric acid can be raised more effectively than by direct uric acid supplementation, and there was also an abstract discussing relapse rates after boosting serum uric acid and it looked pretty good - that one was in my post with the all caps VANISHING LESIONS AND HALTED DISEASE PROGRESS or whatever it was. i will be looking to buy some inosine and introduce it into my regimen once i get to oz.
European Journal of Neurology
Volume 9 Page 221 - May 2002
Volume 9 Issue 3
Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood–brain barrier dysfunction
G. Tonceva, B. Milicicb, S. Toncevc & G. Samardzicd
Several findings suggest lower levels of serum uric acid in multiple sclerosis (MS) patients. The aim of this study is to investigate relationships of uric acid serum levels in relapse–remitting (RR) MS patients with clinical activity of disease and blood–brain barrier (BBB) condition. Sixty-three definite RRMS patients and 40 controls divided into two groups: 20 healthy donors and 20 patients with other inflammatory neurological diseases (OINDs) were analysed. By using a quantitative enzymatic assay according to the manufacture's protocol and a commercial uric acid standard solution, serum uric acid levels were measured and the results were standardized. To investigate BBB function, magnetic resonance imaging after administration of gadolinium was used. MS patients were found to have significantly lower serum uric acid levels (193.89 ± 49.05 μmol/l; mean value ±SD) in comparison with healthy donors (292.7 ± 58.65 μmol/l; P=0.000) and OIND patients (242.7 ± 46.66 μmol/l; P=0.001). We found that MS patients with relapse had significantly lower serum uric acid levels (161.49 ± 23.61 μmol/l) than MS patients with remission (234.39 ± 41.96 μmol/l; P=0.000) and more over, MS patients with BBB disruption had significantly lower serum uric acid levels (163.95 ± 26.07 μmol/l) than those with normal BBB (252.48 ± 25.94 μmol/l; P=0.000). Further, we also found that serum uric acid level independently correlated with disease activity, BBB disruption, and gender. These results indicate that lower uric acid levels in MS patients are associated with relapse and suggest that uric acid might be beneficial in the treatment of MS.