No one can really say. Not even a neuro can say. My neuro refused to give me any kind of prognosis based on the MRI, and that was the correct response. It is frustrating, like everybody newly diagnosed, I wanted to know whether I would be "lucky" or "unlucky", whether I should start any treatment or just wait, etc. I've gone two years with no major problems although I cannot claim to be totally 100% symptom-free. In general, I think my overall health is better than it was for at least a year before the diagnosis, but that could all change. Or I could just continue on like I am. Or maybe I could better, but I'll have to work at it at this point, sitting around won't gain me anything. I was seeing my neuro quarterly, now it is semi-annually. That has given me some encouragement. And like you, I had lots of spots on the MRI. Does it make any sense there is no good correlation between the MRI and symptoms? No. I've read reports that people who have had whole body scans for something unrelated have shown up with lesions on their brain and they've never had any CNS symptoms at all.
In your case, you are taking Rebif and have been over the last year, so you and your doc have some extra incentive to see what is happening on the inside - if you have had no symptoms for a year that is very good. No one can say for the long-term outcome, but it is definitely good right now, and focus on that. It could be due to the natural course (or non-course) of the disease in you, or it could be you are having a good response to the Rebif - either way, that is good. Your lack of symptoms is more important than the MRI in my opinion. People can have normal looking MRIs and a lot of disability, and vice versa, as Amelia and others have said. However, If I were to actually bet, I'd wager your second MRI will look better. I certainly hope so. Keep us posted. You've got us curious.