It seems the only disagreement you and I have is whether or not the immune system is indeed operating appropriately in someone with MS. I think the fact that the immune system makes things worse in MS is inappropriate in itself.
I don't think that the immune system is operating inappropriately in a MS patient. We know that "something" is causing inflammation around an area of myelin. This area is sending a message to the immune system and asking for help. The immune system responds and sends help but whatever is causing the inflammation and the immune system's reaction appears to make things worse.
In the case of the young 17 year old lady who died from a very serious exacerbation, the mechanism that caused the damage did it so quickly and devastatingly enough that the immune system never had time to react. According to Drs. Prineas and Barrett, the immune system wasn't involved so the very big question remains...what on earth caused the myelin to destruct so quickly?!
The docs can use all the fancy immune system altering drugs they want and so far they have used many. Yet, the MS still progresses in patients despite these drugs. In fact, we know that patients who use the CRABs can end up getting much sicker, very quickly. So why? There has to be another reason as to what is causing this myelin destruction.
You can also look at those patients who are into the SPMS phase of the disease. Supposedly the inflammation period has ended but neuron destruction continues to take place. So now we have a different mechanism of degeneration happening. What is causing this?
No wonder they call MS a very perplexing and frustrating disease!