Amelia wrote:When you develop NABS, the interferons are worthless. Or that was the case with Gary. He was on Betaseron and did okay with it. But after about 2 years, he went into a series of attacks. When he stopped the Betaseron altogether, he went into high gear with attacks. Bad ones every 4-6 weeks.
NABs developed during the first three months of treatment and continued to develop until month 18. Over 18 months of treatment, the risk of being persistent NAB+ was 31% for Betaferon, 15% for Rebif, and 2% for Avonex (Betaferon versus Avonex, p = 0.001; Betaferon versus Rebif, p = 0.19; Rebif versus Avonex, p = 0.04). In all patients with one or more NAB+ samples, the risk of becoming NAB+ was 38% for Betaferon, 18% for Rebif, and 7% for Avonex (Betaferon versus Avonex, p = 0.0007; Betaferon versus Rebif, p = 0.10; Rebif versus Avonex, p = 0.07). At month 18, the prevalence of persistent NAB+ patients was 31.6% for Betaferon, 18.7% for Rebif, and 4% for Avonex.
NHE wrote:I have read one paper (which I apologize for not being able to locate in PubMed) which demonstrated that patients with neutralizing antibodies to Betaseron produce no neutralizing antibodies upon switching to Avonex after a months abstention from Betaseron. I know that I have this paper on file, but I'm away from my journal database right now and will post it later once I return.
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