I agree with gwa the lamotrogine trial sounds interesting. It's so nice to have a trial of something that may be neuroprotective to axons.
Now, after people have read your "must read" link, about the immune system, T Cells, etc.....here's another "must read" IMO.
CNS Immune Privilege: Hiding in Plain Sight
CNS autoimmunity and neurodegeneration were presumed automatic consequences of immune cell encounter with CNS antigens. Recent data have dramatically altered this viewpoint by revealing that the CNS is neither isolated nor passive in its interactions with the immune system....
This newer view of CNS immune privilege is opening the door for therapies designed to harness autoreactive lymphocyte responses and also implies (i) that CNS autoimmune diseases (i.e. multiple sclerosis) may result as much from neuronal and/or glial dysfunction as from immune system dysfunctions and (ii) that the severe neuronal and glial dysfunction associated with neurodegenerative disorders (i.e. Alzheimer's disease) likely alters CNS-specific regulation of lymphocyte responses affecting the utility of immune-based therapies (i.e. vaccines).
Remember--I'm not in the auto-immune camp.