Time of day affects severity of autoimmune disease

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Time of day affects severity of autoimmune disease

Postby MSUK » Wed Dec 13, 2017 4:29 am

Insights into how the body clock and time of day influence immune responses have been revealed in a study published in the journal Nature Communications...Read more -http://www.ms-uk.org/time-day-affects-severity-autoimmune-disease

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Re: Time of day affects severity of autoimmune disease

Postby David1949 » Thu Dec 14, 2017 2:12 pm

OK But we aren't mice and EAE is not MS.
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Re: Time of day affects severity of autoimmune disease, etc.

Postby 1eye » Mon Jan 08, 2018 2:01 pm

Some people think MS is not auto-immune, and I think auto-immunity is a crock designed to help nobody but doctors seeking fees. That aside, this business of circadian effects deserves more attention. Mice being nocturnal means any application of work on circadian rhythms on mice has to be initially thought out in terms of the diurnal cycle, and proven to have similar effects on diurnal mammals.

Personally I believe the main effect of MS on me has been to rob me of my energy reserves after about 3PM, which means my life is shortened by maybe 1/4, as without MS I would have been able to be awake and energetic far longer EACH DAY. This is a major circadian effect.

In other news, I got a new kind of AFO of carbon fibre, with two steel springs which assist my dorsiflection. It is much lighter, and makes walking very much easier. I hear my left foot slap when I walk, where before it dragged.

BIOTIN is still improving my life.
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Re: Time of day affects severity of autoimmune disease

Postby David1949 » Mon Jan 08, 2018 3:28 pm

1eye
The new AFO sounds interesting. Is there a name for it or a link to it?

Thanks

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Re: Time of day affects severity of autoimmune disease

Postby 1eye » Thu Jan 11, 2018 11:34 am

David1949 wrote:1eye
The new AFO sounds interesting. Is there a name for it or a link to it?

Thanks

Dave


Apparently there are two versions. I have the single-sided version: http://fillauer.com/Orthotics/Dynamic-Walk.html

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