Yes we need more research in this area. Importantly the page said this
Background: The etiology of multiple sclerosis is currently unknown, but many features of the disease suggest an infectious cause. The clinical course, the inflammatory infiltrates seen on histology, and the oligoclonal bands in the cerebrospinal fluid are all consistent with a recurrent or persistent infection. Similar diseases, such as acute transverse myelitis, acute disseminated encephalomyelitis, and Guillain-Barre syndrome, are linked to infections. And chronic infection with Treponema or Borrelia can cause neurologic disease
The fact that they did not find much may not mean as much as we wish it did though
The most frequent and serious manifestation of disseminated Lyme borreliosis is neuroborreliosis. PCR was applied to 190 patients with untreated and confirmed neuroborreliosis. B. burgdorferi DNA was detectable in 17-21% of CSF samples from patients with neuroborreliosis. In patients with very early neuroborreliosis (< 2 weeks), still being negative for specific intrathecal antibody synthesis, a positive PCR was more frequent than in patients with longer disease duration.
interesting that the longer duration resulted in less PCR positivity- it is odd. Certainly CPn in MS would be a long term infection. But take note this paper was confirmed disease with other manifestations and we have a really low positivity in the CSF. I don't know about you but 17% seems flat awful to me considering these patients are really ill with an already identified serious illness can you imagine if this was the only way they would know they had this?? 83% would be told Nope, negative. Are you kidding me?
This page http://tinyurl.com/nbwcy
mentions the problem of culture speifically
no agent has yet emerged with any consensus as the cause of MS. This controversy is due to a number of factors, including lack of specificity of an agent to MS, lack of reproducibility in other laboratories, inappropriate controls, laboratory contamination and lack of a standard and easily reproducible assay system.
Another recent paper
Chlamydia pneumoniae infection associated with enhanced MRI spinal lesions in multiple sclerosis.Hao Q, Miyashita N, Matsui M, Wang HY, Matsushima T, Saida T.
Department of Neurology, Center for Neurological Diseases, Utano National Hospital, Kyoto, Japan.
Cerebrospinal fluid (CSF) from 66 patients with multiple sclerosis (MS) and 25 patients with other neurological diseases (OND) were examined for the infection of Chlamydia pneumoniae by culture, polymerase chain reaction (PCR) assay, and determination of antibodies to C. pneumoniae. PCR was positive not only in 9 of 28 (32%) patients with MS but also in 2 patents with inflammatory disorders in 15 (13%) OND controls (p = 0.18). Viable C. pneumoniae was isolated from one patient with MS and one with paraneoplastic encephalomyelitis. C. pneumoniae could be detected only in cell-containing CSF. In MS, enhanced spinal magnetic resonance imaging (MRI) lesions were detected in all of four PCR-positive patents but none of five PCR-negative patients, and the difference was significant (p = 0.0079). However, no correlation was found between enhanced brain MRI lesions and CSF C. pneumoniae DNA. Elevated titers of anti-C. pneumoniae IgG were detected in CSF in 13 of 66 (20%) patients with MS and 1 of 25 (4%) OND controls (p = 0.064). CNS C. pneumoniae infection is not uncommon in MS as well as in other inflammatory disorders of the nervous system. The association of active spinal lesions with Chlamydia in CSF collected by lumber puncture suggests the detection of a recent infection. On the other hand, the lack of association of active MS brain lesions with CSF Chlamydia and the presence of PCR-positive patents who are clinically stable and have no enhancing MRI lesions imply the existence of a chronic infectious process.
PMID: 12356213 [PubMed - indexed for MEDLINE]
So of course we are back to the old you have your scientist and I have a different one, so who's got the right guy? This hasn't been resolved and we keep seeing papers on this as there IS a lot of material on both sides. This is science in progress. I read a paper recently that stated that it takes a 33% agreement with a new paradigm before the "tipping point" occurs and the old thought gives way to the new idea We have a ways to go before we reach consensus