T Reg cells

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T Reg cells

Postby bromley » Mon Oct 09, 2006 2:08 pm

I know it's EAE, but I think we'll be hearing a lot more about T Reg cells in the future.

http://www.msif.org/en/research/researc ... expan.html
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T Reg Cells and Estrogen

Postby Shayk » Mon Oct 09, 2006 7:20 pm

Hi Ian

I think estrogen might be something they're looking at re: T Reg Cells.

Here's a dry abstract on the topic.
Estrogen (E2)-induced immunomodulation involves dual effects on antigen-presenting cells (APC) and CD4(+)CD25(+) regulatory T cells (Treg) but not a direct effect on effector T cells.

That study builds on earlier research--Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment.

I hope we hear more about estrogen. :wink: I'm fearful it's going to go undercover rapidly since they they're still trying to find funding for the Phase II estriol trial (with Copaxone no less). :(

Sharon
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