Immune system "modulation"

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Immune system "modulation"

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:33 am, edited 2 times in total.
User avatar
Libreni
Getting to Know You...
Posts: 20
Joined: Wed Sep 13, 2006 2:00 pm
Location: Indianapolis
Contact:

Post by Libreni »

nope, can't read it. It gives me an error message about cookies. :(
sh8un
Family Elder
Posts: 303
Joined: Wed May 03, 2006 2:00 pm
Location: Calgary, AB, Canada

Post by sh8un »

I got cookies too!
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

cookies

Post by jimmylegs »

i can read it - could be a browser setting causing cookie issues?
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:33 am, edited 4 times in total.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

10 30 with the c&p of the 10 36

Post by jimmylegs »

jeez lyon if it is, then i'm on the wrong side of the law for sure!
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Immune Sytem

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:34 am, edited 1 time in total.
User avatar
jimmylegs
Volunteer Moderator
Posts: 12592
Joined: Sat Mar 11, 2006 3:00 pm

the itos of jimmylegs

Post by jimmylegs »

ya it's either that or a burrito, depends on what mood i'm in at the time ;)
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Re: the itos of jimmylegs

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:34 am, edited 1 time in total.
User avatar
CureOrBust
Family Elder
Posts: 3374
Joined: Wed Jul 27, 2005 2:00 pm
Location: Sydney, Australia

Post by CureOrBust »

A little more on what / how they technically effect the immune system to not attack. I found this site (that are actually out to kill them, but hey....)
NK cell binding protein (NKBP) - chronic hookworm infections in humans are marked by high levels of IL-10 and depressed levels of IL-4, a surprising finding given the elevated levels of IL-4 in other helminth infections. We have identified secreted proteins of the human hookworm, Necator americanus, which bind specifically to Natural Killer cells and no other cell type. Moreover, these proteins induce NK cells to secrete high levels of IFN- , an intriguing finding given the absence of a pronounced Th2 response (usually associated with immune clearance of helminths) in human hookworm infections. Future work in this area will explore the effects of hookworm secretory products on the inability of humans to mount protective immune responses to this pathogen. We will also purify the NK cell-binding protein, identify its NK cell receptor, and explore its potential as a pro-inflammatory adjuvant and specific marker for NK cells.
http://www.qimr.edu.au/research/labs/alexl/index.html
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:34 am, edited 1 time in total.
User avatar
ljm
Family Elder
Posts: 153
Joined: Wed Mar 30, 2005 2:00 pm

Post by ljm »

Cureo, great link. Bob, in your other thread you said that everything you're learned about MS sort of supports the parasite theory. Can we throw stuff at you, see if it bounces? (or whatever that expression is)

Lets accept parasites. How does that explain RR, why do people have "attacks" of immune overactivity? Why do those attacks gradually disappear and replace by the steady, relentless decline of PP?

(I think cureo and I should be first guiness pigs on this)
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:35 am, edited 1 time in total.
User avatar
ljm
Family Elder
Posts: 153
Joined: Wed Mar 30, 2005 2:00 pm

Post by ljm »

I guess my problem is that even if parasites provide to be immuno-suppressant, or even better, immuno-modulatory, they're only going to address the part of MS that is all the pharmas currently address.. Thats not insignificant, and if parasites do it better than the pharmas it might slow progression of the disease to the point that you can easily outlive it. Yeah, I could live with that. But neurodegeneration, the process that carries the second act of the disease, the PP part, it isn't caused by immune system, it seems to happen in parallel with auto immune attacks and despite any suppression/modulation. I think that does matter, its the black hole, it worries me more than the thought of my gut wriggling with worms ever would.
Lyon
Family Elder
Posts: 6071
Joined: Wed May 03, 2006 2:00 pm
Contact:

Post by Lyon »

oo
Last edited by Lyon on Sat May 07, 2011 9:35 am, edited 1 time in total.
Post Reply
  • Similar Topics
    Replies
    Views
    Last post

Return to “General Discussion”