Immune system "modulation"

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Immune system "modulation"

Postby Lyon » Thu Oct 12, 2006 12:31 pm

oo
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Postby Libreni » Fri Oct 13, 2006 4:47 am

nope, can't read it. It gives me an error message about cookies. :(
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Postby sh8un » Fri Oct 13, 2006 6:25 am

I got cookies too!
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cookies

Postby jimmylegs » Fri Oct 13, 2006 6:57 am

i can read it - could be a browser setting causing cookie issues?
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Postby Lyon » Fri Oct 13, 2006 12:08 pm

oo
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10 30 with the c&p of the 10 36

Postby jimmylegs » Fri Oct 13, 2006 4:54 pm

jeez lyon if it is, then i'm on the wrong side of the law for sure!
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Immune Sytem

Postby Lyon » Fri Oct 13, 2006 5:55 pm

oo
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the itos of jimmylegs

Postby jimmylegs » Fri Oct 13, 2006 10:19 pm

ya it's either that or a burrito, depends on what mood i'm in at the time ;)
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Re: the itos of jimmylegs

Postby Lyon » Sat Oct 14, 2006 7:43 pm

oo
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Postby CureOrBust » Fri Nov 17, 2006 7:46 pm

A little more on what / how they technically effect the immune system to not attack. I found this site (that are actually out to kill them, but hey....)

NK cell binding protein (NKBP) - chronic hookworm infections in humans are marked by high levels of IL-10 and depressed levels of IL-4, a surprising finding given the elevated levels of IL-4 in other helminth infections. We have identified secreted proteins of the human hookworm, Necator americanus, which bind specifically to Natural Killer cells and no other cell type. Moreover, these proteins induce NK cells to secrete high levels of IFN- , an intriguing finding given the absence of a pronounced Th2 response (usually associated with immune clearance of helminths) in human hookworm infections. Future work in this area will explore the effects of hookworm secretory products on the inability of humans to mount protective immune responses to this pathogen. We will also purify the NK cell-binding protein, identify its NK cell receptor, and explore its potential as a pro-inflammatory adjuvant and specific marker for NK cells.


http://www.qimr.edu.au/research/labs/alexl/index.html
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Postby Lyon » Fri Nov 17, 2006 7:56 pm

oo
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Postby ljm » Fri Nov 17, 2006 8:28 pm

Cureo, great link. Bob, in your other thread you said that everything you're learned about MS sort of supports the parasite theory. Can we throw stuff at you, see if it bounces? (or whatever that expression is)

Lets accept parasites. How does that explain RR, why do people have "attacks" of immune overactivity? Why do those attacks gradually disappear and replace by the steady, relentless decline of PP?

(I think cureo and I should be first guiness pigs on this)
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Postby Lyon » Fri Nov 17, 2006 8:58 pm

oo
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Postby ljm » Sat Nov 18, 2006 5:46 pm

I guess my problem is that even if parasites provide to be immuno-suppressant, or even better, immuno-modulatory, they're only going to address the part of MS that is all the pharmas currently address.. Thats not insignificant, and if parasites do it better than the pharmas it might slow progression of the disease to the point that you can easily outlive it. Yeah, I could live with that. But neurodegeneration, the process that carries the second act of the disease, the PP part, it isn't caused by immune system, it seems to happen in parallel with auto immune attacks and despite any suppression/modulation. I think that does matter, its the black hole, it worries me more than the thought of my gut wriggling with worms ever would.
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Postby Lyon » Sat Nov 18, 2006 7:21 pm

oo
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