Accelerated Cure Project

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Accelerated Cure Project

Postby bromley » Wed Oct 25, 2006 11:37 am

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blood samples

Postby gwa » Wed Oct 25, 2006 12:15 pm

I am liking the fact that they are wanting blood and tissue samples from living patients.

Too many tissue research is done postmortem when the person can't answer questions.

gwa
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Postby marcstck » Wed Oct 25, 2006 1:13 pm

I'm taking part in this. Have an 80 page survey to fill out (mostly on genetic background), this Friday I go in to have blood drawn and spend two hours being interviewed by a research associate. I became involved though my neurologist's office...
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relatives

Postby gwa » Thu Oct 26, 2006 11:51 am

marcstock,

Are you the only person in your familywith MS?

gwa
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Postby marcstck » Thu Oct 26, 2006 12:04 pm

Yes, but my Mom came down with type 1 diabetes when she was pregnant with me. Could there be one pathogen triggering both diseases? She has also developed Parkinson's, later in life...
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ACP

Postby Muu » Thu Oct 26, 2006 12:47 pm

This makes such perfect sense.
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Postby ljm » Sat Oct 28, 2006 12:27 pm

I really like the idea of accelerated cure taking on one, big project that can help multiple research endeavors, its an incredible contribution.
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Postby bromley » Sat Oct 28, 2006 2:06 pm

GWA wrote:

I am liking the fact that they are wanting blood and tissue samples from living patients.


I wouldn't like to meet you on Halloween!

GWA wrote:

Too many tissue research is done postmortem when the person can't answer questions.


I have an aunt who's a psychic if you think that might help? What questions would you like them to answer?

Ian
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Knowledge from "Beyond'

Postby gwa » Sat Oct 28, 2006 3:16 pm

Ian,

Please ask your aunt to talk to Richard Pryor (dead American comic that had MS) and ask him to find out what causes MS.

He should be in a place now that has all the answers. :wink:

gwa
Last edited by gwa on Sat Oct 28, 2006 6:28 pm, edited 1 time in total.
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richard pryor and ms

Postby jimmylegs » Sat Oct 28, 2006 5:20 pm

i searched on "cocaine oxidative stress" in google. looks like a bunch of familiar terminology doesn't it!

http://cat.inist.fr/?aModele=afficheN&cpsidt=14680131
The objective of the present study was to verify if immunosuppression caused by cocaine (CO) can be mediated, at least in part, by increased formation of oxidative metabolites and reactive oxygen species (ROS) in rat. Pharmacokinetics of cocaine and its metabolites, cell-mediated immune function and cytokines production, biomarkers of cell redox state maintenance and lipidic peroxidation, and variations of activity in the enzymatic systems involved in cell antioxidant defence were measured in spleen of Wistar rats acutely and chronically treated with cocaine. C[max], AUC, and 1[1]/2 of norcocaine (NC) significantly increased after chronic exposure to cocaine while kinetic parameters of benzoylecgonine (BE) significantly decreased. A decrease in cultured T-lymphocytes proliferation and natural killer (NK) cell activity, a high increase of immunosuppressive cytokines and a switch from Th1-type cytokines to Th2-type cytokines together with an unbalance toward anti-inflammatory cytokines recovered within 4 h after acute treatment while subsisted for 14 days after chronic treatment. A significant increase in ascorbic acid (AA), reduced glutathione and glutathione reductase (GR) with a simultaneous decrease in oxidized glutathione were observed in the first hours after acute administration. Conversely, the increase in oxidized glutathione and malondialdehyde (MDA) production and the simultaneous depletion of reduced glutathione and ascorbic acid persisted at least 24 h after chronic cocaine treatment as well as the increase in the activities of glutathione reductase, glutathione peroxidase (GPx) and superoxide dismutase (SOD). The results suggest that chronic cocaine administration affects cellular enzyme and non-enzyme-mediated antioxidant defence systems and promotes immunotoxicity in rat. Cocaine N-oxidative metabolism may be an indirect contributor, via oxidative stress.
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