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"Drug-induced Tremor: Certain drugs are known to induce or worsen tremor in some patients. Table 2 provides a list of some of the most common agents in this category. For example, levetiracetam (Keppra), typically used to treat epilepsy, was reported to worsen ET {essential tremor} in 5 out of 10 patients in an open label study (Ondo, Jimenez, Vuong & Jankovic, 2004). In patients with MS, drugs such as prednisone or antidepressants are common causes of tremor.
Table 2: Drugs with potential to induce tremor.
Caffeine, Lithium, Cyclosporin, Methylxanthines, Tacrolimus, Bronchodilators, Valproic acid, Antidepressants, Neuroleptics, Antiemetics, Reserpine, Prednisone, Amiodarone, Tocainide, Stimulants, Metronidazole, Alcohol withdrawal, Levetiracetam."

Irreversible Neurological Worsening Following High-dose Corticosteroids in Advanced Progressive MS

Administration of a course of high-dose corticosteroids has been indicated to accelerate recovery from a relapse of MS. Some patients with progressive MS seek a course of corticosteroid treatment outside a relapse, in the hope of gaining some improvement in function. Two Dutch researchers in the Department of Neurology at the University Medical Center Groningen described four patients with advanced progressive MS who experienced worsening of disability after treatment with high-dose corticosteroids. The findings of their study can be read in the January-February 2006 issue of Clinical Neuropharmacology.

All four patients reported moderate to severe disability and sought corticosteroid treatment because they were slowly progressing. None had experienced a relapse. Each patient experienced improvement by the end of therapy, however, within 1 or 2 days after discontinuing treatment, they had worsened to a state more clinically disabled than before treatment occurred. Therefore, the authors note that the use of high-dose corticosteroid therapy in progressive forms of MS outside relapses can be detrimental and actually result in worsened disability.

(Available from: http://www.pubmed.gov PMID: 16518129)