Your response is the exact reason I asked the question. I just underwent a total hysterectomy on Nov 9. But..... I can't take hormones because I also had a bout of breast cancer this summer which was removed surgically then went through radiation (2006 has NOT been my year). So no hormone replacement for me. Your answer scares me to death because it is exactly what I was thinking could occur. So far I've been fine...
... I am trying very hard not to freak out because I know THAT is not helpful for my MS.
I am not sure who to turn to for research into all of this because I cannot possibly be the first MS patient with MS to have had breast cancer or the first breast cancer patient with MS.
the risk of cancer following diagnosis of MS
Overall 1,037 cancers were observed in 11,817 MS patients during 153,875 person-years of follow-up vs. an expected number of 1,098
Though the overall cancer risk was not increased…..female MS patients had an increased risk of breast cancer.
In general MS patients are not at increased risk of cancer. Women with MS, however, seem to have a small excess risk of breast cancer, which cannot be attributed to reduced parity or delayed first child birth.
Among 892 female MS patients, 15 (1.7%) developed breast cancer, and 31 (3.5%) developed cancers of any type. Seventeen of 446 (3.8%) male MS patients developed cancer.
Our findings indicate that cancer incidence is significantly lower in female MS patients than in the general population.
Female MS patients treated with glatiramer acetate showed an elevated rate of breast cancer and all MS patients treated with beta-interferons showed an elevated risk of non-breast cancers though not statistically significant (p = 0.122 and 0.072, respectively).
Further study is needed to assess possible associations between long-term exposure to the novel immunomodulatory treatments in MS and rate of cancer.
Our findings implicate mitochondrial dysfunction induced by protein inactivation and mediated by oxidative stress initiates a cascade of molecular events leading to apoptosis and neurodegeneration in experimental autoimmune encephalomyelitis that is not mediated by inflammatory cells.
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