But Harry, even 13 or 14 biopsies is too small of a sample size when the results are only attributible to two researchers working together.
Too small a sample size for what? Prineas and Barrett weren't trying to prove anything but ended up discovering that the auto-immune system simply wasn't involved in causing the demyelination in these particular cases. This is a very interesting discovery because up until this time, the researchers were "fixated" on the immune system as the only culprit in MS.
It is stated that the immune system goes after myelin when it detects inflammation. That is a normal response. But what some researchers say is that the immune system is reacting to the inflammation as opposed to causing it. With MS being a long time,chronic disease, I would imagine that most brain autopsies would show some kind of immune system activity since it would take years and years for the patient to succumb to the disease. Finding what Prineas and Barrett did would be quite rare and obviously difficult to duplicate. Obviously you don't take brain biopsies of MS patients who are experiencing an attack so it's all but impossible to determine first hand what is happening to the myelin at that time.
If MS were an auto-immune system disease, then I would think that the CRAB drugs, over the years, would have had a far greater effect on controlling the disease. That simply isn't the case and their results have been poor at best.
At lease now, researchers have an option to look at and perhaps be able to answer a few more questions about this mysterious disease.