Chris55 wrote:Touche' my friend! Harry, when I first read your post I thought it said you "disagreed" with everything I said--LOL!
I think the CRAB drugs outlived their usefulness a long time ago. I get a kick out of reading their trial results--for me, totally manipulated and totally unproveable because there is NOTHING consistent with this disease from person to person. Everytime my daughter had a non-typical MS symptom--poof! it became a new MS symptom! (Or more insulting, "in her head".)
I have no solution for the CRAB drug monopoly but as many of you already know, I definitely support alternative treatments as long as they do no harm!
There's lots of room on this site for a variety of opinions though!
Murine models of CNS injury show auto-reactive T cell responses directed at myelin antigens, associated with improved neuronal survival and functional recovery. This pilot study shows, for the first time, that similar immune responses against myelin occur in human traumatic brain injury (TBI), with an expansion of lymphocytes recognising myelin basic protein observed in 40% of patients studied. "Reactive" patients did not have greater contusion volume on imaging, but were younger than the "unreactive" subgroup and tended towards a more favorable outcome. These findings are consistent with the concept of "beneficial autoimmunity".
Chris55 wrote:Autopsies were done on 2 MS patients who died while in the middle of a relapse. Their brains were actually studied. What they found were dead/dying myelin-producing cells AND they were NOT killed by T cells. That pretty much shoots the autoimmune theory out the window for me.
I'm not trying to argue one way or the other, but a sample size of 2 is hardly conclusive. At most, that study represents interesting data that will hopefully lead to further investigations.
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