Team Project: List of every MS Treatment currently in trials

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Team Project: List of every MS Treatment currently in trials

Postby Arron » Wed Aug 11, 2004 4:26 pm

Allright everybody, it is time for a team effort.

This is MS would like to pull together (and maintain) a document showing every drug that is currently in clinical trials for the treatment of Multiple Sclerosis (or its effects, such as fatigue), what phase it is in, who makes it, main mode of action, preliminary results, etc.

While we can get quite far ourselves, this seemed like a great opportunity to get the community involved. We hope that many of you will contribute to this project-- if you think of it like a scavenger hunt, it could be quite fun. Of course, there are shortcuts to getting a lot of the information at once, such as locating other documents that attempt to do something similar. However, we are not satisfied with what is out there today and we know we can do better. Our aim is to create a resource that is more thorough, easier to read and understand, and makes it clear where to find out more information (such as how to participate in a given trial...).

Furthermore, we know that the way to achieve that is to involve our brilliant, tenacious members.

Any help any person can provide will be greatly appreciated.

A good template to use is as follows, but feel free to present data in any way you want. We will take all the inputs here, add whatever is missing, and produce a document we will actively maintain.

The message of this project is HOPE. There is an incredible amount of research going on!

Name of drug/compound:
Manufacturer:
Location:
Current FDA Phase: (I/II/III/IV)
Treatment for: (MS Progression/MS Fatigue/etc.)
Intended for ___ MS Sub-types (Relapsing-Remitting, etc.)
Mode of Action: (how it works)
Mode of Application: (e.g., Injection/IV/etc.)
Website for more information:
Last edited by Arron on Tue Jan 24, 2006 3:52 am, edited 2 times in total.
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Postby treez » Thu Aug 12, 2004 4:34 am

Fabulous Idea, I think most all of them are here in the forum but with all the posts, who has time to actually go through and read all the posts. Isn't that what this board is all about..............bringing it all together. Will the results be presented on a page designed spesifically for presentation of this data (just a suggestion) ?

Willing to help.....This is my HOPE

treez
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Postby mscaregiver » Thu Aug 12, 2004 6:16 am

Name of drug/compound: Low Dose Naltrexone (LDN)
Manufacturer: Pharmacy compounded
Location: World wide
Current FDA Phase: (none known specific)
Treatment for: (MS Progression/MS Fatigue/etc.)
Intended for _All__ MS Sub-types (Relapsing-Remitting, etc.)
Mode of Action: (Still in research)
Mode of Application: (Oral)
Website for more information: http://www.lowdosenaltrexone.org/
Last edited by mscaregiver on Thu Aug 12, 2004 6:53 am, edited 1 time in total.
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Postby mscaregiver » Thu Aug 12, 2004 6:32 am

Name of drug/compound: Minocycline
Manufacturer: Wyeth Ayerst Pharmaceuticals
Location: World Wide Corporation
Current FDA Phase: (?)
Known related trial: (amyotrophic lateral sclerosis (ALS). PhaseIII
ALS trial info: http://www.clinicaltrials.gov/ct/show/NCT00047723
Treatment for: (MS Progression/MS Fatigue/etc.)
Intended for _All__ MS Sub-types (Relapsing-Remitting, etc.)
Mode of Action: Minocycline is a second generation tetracycline that is known to have immune modulating properties
Mode of Application: (Oral)
Website for more information: http://www.cnsforum.com/cp/en/CNSforum/literature/trial_reports/reports/934221.html
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Postby mscaregiver » Thu Aug 12, 2004 6:53 am

Name of drug/compound: Daclizumab (trade name Zenapax)
Manufacturer: Hoffmann-La Roche Inc. (Roche),
Location: Nutley, N.J., (U.S. division of the Roche Group)
Current FDA Phase: (none known as specific)
Known Trail: Small 11 patient
Known trial info: docguide.com
Treatment for: (MS Progression/MS Fatigue/etc.)
Intended for _All__ MS Sub-types (Relapsing-Remitting, etc.)
Mode of Action: Add on treatment in conjuction with beta interferon..
Mode of Application: (intravenously)
Website for more information:
docguide.com
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Postby mscaregiver » Thu Aug 12, 2004 7:34 am

Name of drug/compound: Simvastatin (Zocor)
Manufacturer: Merck & Co., Inc.)
Location: World Wide Corporation
Current FDA Phase: (none known specific)
Known Trial :
A small clinical trial was done of the oral cholesterol-lowering drug Zocor® in 30 individuals with relapsing-remitting MS:
Zocor appeared to reduce the number of new MRI-detected brain lesions over the six-month treatment period, and demonstrated other signs of possible benefit;
Previous studies have suggested that this and other statin drugs can alter immune responses in a way that may be beneficial for treating MS;
Larger, controlled trials will be required to determine the drug’s safety and effectiveness against MS; such trials are in planning stages.

Treatment for: (MS Progression/MS Fatigue/etc.)
Intended for _All__ MS Sub-types (Relapsing-Remitting, etc.)
Mode of Action: Previous studies have suggested that cholesterol-lowering “statins” can alter immune responses
Mode of Application: Oral
Website for more information:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15145635&dopt=Abstract
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Postby mscaregiver » Thu Aug 12, 2004 7:45 am

Name of drug/compound: Gemfibrozil (Lopid)
Manufacturer: Pfizer
Location: World Wide Corporation
Current FDA Phase: (none known specific)
Known Trail : (none known specific
Treatment for: (MS Progression/MS Fatigue/etc.)
Intended for _All__ MS Sub-types (Relapsing-Remitting, etc.)
Mode of Action: Gemfibrozil is a lipid regulating agent
Mode of Application: Oral
Website for more information:
http://app1.unmc.edu/publicaffairs/todaysite/sitefiles/today_full.cfm?match=1375http://www.medicinenet.com/gemfibrozil/article.h
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Postby Arron » Thu Aug 12, 2004 10:36 am

Thanks Philip, keep it coming!

Treez, we intend to gather the information from this post and our own research, package it up in an easy-to-understand format, and post it as a download or web page.
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Postby dignan » Thu Aug 12, 2004 12:07 pm

I'm taking the lazy way out here, but this is a link to a really good summary put together in April 2004 by ING on the "MS Market" which includes a great listing of therapies in the clinical trial process.

http://sykepleier.net/filer/ms_market_report.pdf
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Postby Arron » Thu Aug 12, 2004 2:34 pm

Awesome, but that's not all there is! More, More! :twisted:
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Postby finn » Thu Aug 12, 2004 2:34 pm

Sorry, time to leave the board.

-finn
Last edited by finn on Sun Aug 28, 2005 9:34 am, edited 1 time in total.
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Postby dignan » Thu Aug 12, 2004 4:31 pm

Name of drug/compound: NeuroVax
Manufacturer: Immune Response Corporation
Location: Carlsbad, California
Current FDA Phase: II
Treatment for: disease progression
Intended for RRMS Sub-types
Mode of Action: NeuroVax is composed of a combination of TCR peptides from three families (BV5S2, BV6S5, and BV13S1) with an adjuvant to improve immune response rates.
Mode of Application: injection?
Website for more information: http://www.imnr.com/
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Postby dignan » Thu Aug 12, 2004 4:44 pm

Name of drug/compound: Pixantrone
Manufacturer: Cell Therapeutics
Location: Seattle
Current FDA Phase: n/a - planning phase I in near future
Treatment for: MS Progression
Intended for RRMS/SPMS Sub-types
Mode of Action: analogue of mitoxantrone
Mode of Application: intravenous
Website for more information: http://www.cticseattle.com/
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Postby dignan » Thu Aug 12, 2004 4:51 pm

Name of drug/compound: Aimspro
Manufacturer: Daval International
Location: UK
Current FDA Phase: II (?) - not FDA?
Treatment for: MS Progression
Intended for RRMS/PPMS/SPMS Sub-types
Mode of Action: vaccine induced bioactive effector complex - polyclonal antibodies - anti-inflamatory properties
Mode of Application: subcutaneous injection
Website for more information: http://www.davalinternational.com
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Postby dignan » Thu Aug 12, 2004 4:59 pm

Name of drug/compound: Alferon N Injection (alpha interferons)
Manufacturer: Hemispherx Biopharma, Inc.
Location: Philadelphia
Current FDA Phase: II
Treatment for: MS Progression
Intended for RRMS Sub-types
Mode of Action: immune-modulation (aren't they still trying to conclusively figure out just what interferons do that is helpful in MS?)
Mode of Application: injection
Website for more information: http://www.hemispherx.net/
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