gwa wrote:My experience with steroids was that for the first 10 or so years, during flares, they made me better, although I still had lingering symptoms that never totally cleared up each time.
gwa wrote:The last time I was put on them I had so many side effects that I decided I would never take them again.
gwa wrote:Another thing about taking steroids is that they decline in effectiveness over time and end up not being of much benefit for symptom relief.
Is it documented anywhere exactly what action of the steroids fail in the long term?
Hate to repeat myself, but I still dont understand what stops working with steroids after long term usage?
Insensitivity to glucocorticoid and beta-adrenergic modulation might be involved in overshooting inflammation in MS, whereas hyperactivity of the HPA axis has been linked to neurodegeneration and increased disability.
found a trend towards worsening of clinical status over time with increasing corticosteroid resistance. These data suggest that corticosteroid sensitivity may be a factor in the pathogenesis and could be used for prognosis of MS.
CONCLUSION: The use of high-dose corticosteroid therapy in progressive forms of MS outside relapses can be detrimental and worsen disability.
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